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APOBEC3C Antibody

APOBEC3C Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAPOBEC3C Primary Polyclonal Antibody
Also known asAPOBEC3C PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAPOBEC3C
SpecificityThis is a highly specific antibody against APOBEC3C
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APOBEC3C
Gene ID number27350
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, Interestingly, Like APOBEC3G, The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22, This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention, Thus, Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome, and are also likely contribute to sequence variation observed in many viruses, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, resulting in G to A hypermutation in the plus strand of DNA, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication, APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names APOBEC1 like, APOBEC1-like, APOBEC1L, APOBEC3C, ARDC2, ARDC4, ARP5, Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C, MGC19485, PBI, Phorbolin I, Phorbolin I protein, Probable DNA dC dU editing enzyme APOBEC 3C, Probable DNA dC->, bK150C2, 3, ABC3C_HUMAN, dU-editing enzyme APOBEC-3C
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAPOBEC3C
Short nameAPOBEC3C Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAPOBEC3C (Antibody to)
Alternative techniqueantibodies
Identity 17353
Gene APOBEC3C
Long gene name apolipoprotein B mRNA editing enzyme catalytic subunit 3C
Synonyms gene name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Synonyms APOBEC1L PBI bK150C2, 3 ARDC2 ARDC4 ARP5
Locus 22q13, 1
Discovery year 2001-12-12
GenBank acession AF165520
Entrez gene record 27350
Pubmed identfication 11863358
RefSeq identity NM_014508
Classification Apolipoprotein B mRNA editing enzyme catalytic subunits
Havana BLAST/BLAT OTTHUMG00000151087

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