| Category | Antibody |
| Concentration | 2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form | Antigen affinity purified |
| Conjugation | Unconjugated |
| Clone | Polyclonal antibody |
| Recognised antigen | APP (Amyloid beta) |
| Host animal | Rabbit (Oryctolagus cuniculus) |
| Clonality | Polyclonal (rabbit origin) |
| Species reactivity | Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications | IHC-P, WB |
| Recommended dilutions | 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes | Titration of the APP antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use | This APP antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot # | P05067 |
| Purity | Antigen affinity |
| Description | APP is best known and most commonly studied as the precursor molecule whose proteolysis generates Amyloid beta (Abeta), Alpha-secretase generates soluble amyloid protein, Its primary function is not known, The protein undergoes posttranslational proteolytic processing by alpha-, These two processing pathways are mutually exclusive, a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimers disease patients, and gamma-secretases, beta-, neural plasticity and iron export, though it has been implicated as a regulator of synapse formation, while beta- and gamma-secretases generate APP components with amyloidogenic features, Amyloid precursor protein is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons |
| Immunogen | mouse and rat), An amino acid sequence from the N-terminus of human Amyloid beta (EVPTDGNAGLLAEPQ) was used as the immunogen for this APP antibody (100% homologous in human |
| Storage | Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the APP antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target | APP (Amyloid beta) |
| Short name | APP Antibody (Amyloid beta) |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | amyloid beta (A4) precursor protein (Antibody to) (Amyloid b) |
| Alternative technique | antibodies |
| Alternative to gene target | AAA and ABETA and ABPP and AD1 and APPI and CTFgamma and CVAP and PN-II and PN2, APP and IDBG-1100 and ENSG00000142192 and 351, APP and IDBG-630293 and ENSBTAG00000017753 and 280722, App and IDBG-172954 and ENSMUSG00000022892 and 11820, growth factor receptor binding, leucine rich repeat containing receptor signaling pathway and biological process this GO :0040014 and regulation of multicellular organism growth and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043197 and dendritic spine and cellular component this GO :0043198 and dendritic shaft and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043235 and receptor complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045177 and apical part of cell and cellular component this GO :0045202 and synapse and cellular component this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045931 and positive regulation of mitotic cell cycle and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046914 and transition metal ion binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048669 and collateral sprouting in absence of injury and biological process this GO :0050803 and regulation of synapse structure and activity and biological process this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0051124 and synaptic growth at neuromuscular junction and biological process this GO :0051233 and spindle midzone and cellular component this GO :0051402 and neuron apoptotic process and biological process this GO :0051425 and PTB domain binding and molecular function this GO :0051563 and smooth endoplasmic reticulum calcium ion homeostasis and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070851 and growth factor receptor binding and molecular function, nuclei, this GO :0000085 and mitotic G2 phase and biological process this GO :0001967 and suckling behavior and biological process this GO :0002576 and platelet degranulation and biological process this GO :0003677 and DNA binding and molecular function this GO :0004867 and serine-type endopeptidase inhibitor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005641 and nuclear envelope lumen and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005905 and coated pit and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006378 and mRNA polyadenylation and biological process this GO :0006417 and regulation of translation and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006878 and cellular copper ion homeostasis and biological process this GO :0006897 and endocytosis and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007155 and cell adhesion and biological process this GO :0007176 and regulation of epidermal growth factor-activated receptor activity and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007409 and axonogenesis and biological process this GO :0007596 and blood coagulation and biological process this GO :0007617 and mating behavior and biological process this GO :0007626 and locomotory behavior and biological process this GO :0008088 and axon car this GO transport and biological process this GO :0008201 and heparin binding and molecular function this GO :0008203 and cholesterol metabolic process and biological process this GO :0008344 and adult locomotory behavior and biological process this GO :0008542 and visual learning and biological process this GO :0009986 and cell surface and cellular component this GO :0010468 and regulation of gene expression and biological process this GO :0010951 and negative regulation of endopeptidase activity and biological process this GO :0010952 and positive regulation of peptidase activity and biological process this GO :0010971 and positive regulation of G2/M transition of mitotic cell cycle and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016199 and axon midline choice point recognition and biological process this GO :0016322 and neuron remodeling and biological process this GO :0016358 and dendrite development and biological process this GO :0016504 and peptidase activator activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030134 and ER to this GO lgi transport vesicle and cellular component this GO :0030168 and platelet activation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030424 and axon and cellular component this GO :0030900 and forebrain development and biological process this GO :0031093 and platelet alpha granule lumen and cellular component this GO :0031175 and neuron projection development and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031594 and neuromuscular junction and cellular component this GO :0033130 and acetylcholine receptor binding and molecular function this GO :0035235 and ionotropic glutamate receptor signaling pathway and biological process this GO :0035253 and ciliary rootlet and cellular component this GO :0035872 and nucleotide-binding domain, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0004867: serine-type endopeptidase inhibitor activity and also this GO :0005102: receptor binding and also this GO :0005515: protein binding and also this GO :0008201: heparin binding and also this GO :0016504: peptidase activator activity and also this GO :0019899: enzyme binding and also this GO :0033130: acetylcholine receptor binding and also this GO :0042802: identical protein binding and also this GO :0046914: transition metal ion binding and also this GO :0051425: PTB domain binding and also this GO :0070851: growth factor receptor binding, this GO :0004867: serine-type endopeptidase inhibitor activity, this GO :0005102: receptor binding, this GO :0005515: protein binding, this GO :0008201: heparin binding, this GO :0016504: peptidase activator activity, this GO :0019899: enzyme binding, this GO :0033130: acetylcholine receptor binding, this GO :0042802: identical protein binding, this GO :0046914: transition metal ion binding, this GO :0051425: PTB domain binding, this GO :0070851: growth factor receptor binding, amyloid beta (A4) precursor protein |
| Identity | 620 |
| Gene | APP |
| Long gene name | amyloid beta precursor protein |
| Synonyms gene | AD1 |
| Synonyms gene name | Alzheimer disease amyloid beta (A4) precursor protein |
| Synonyms name | peptidase nexin-II |
| Locus | 21q21, 3 |
| Discovery year | 1986-01-01 |
| GenBank acession | M15533 |
| Entrez gene record | 351 |
| Pubmed identfication | 1679289 |
| RefSeq identity | NM_000484 |
| Classification | Endogenous ligands |
| Havana BLAST/BLAT | OTTHUMG00000078438 |
| Locus Specific Databases | Alzheimer Disease &, Frontotemporal Dementia Mutation Database |
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