| Category | Antibody |
| Concentration | 2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form | Antigen affinity purified |
| Conjugation | Unconjugated |
| Clone | Polyclonal antibody |
| Recognised antigen | Aryl Hydrocarbon Receptor / AHR |
| Host animal | Rabbit (Oryctolagus cuniculus) |
| Clonality | Polyclonal (rabbit origin) |
| Species reactivity | Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications | WB |
| Recommended dilutions | 1-0, 5ug/ml, Western blot: 0 |
| Notes | Optimal dilution of the AHR antibody should be determined by the researcher |
| Intented use | This AHR antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot # | P30561 |
| Purity | Antigen affinity |
| Description | Activation of Ahr during induction of EAE accelerated disease onset and increased pathology in wildtype mice, AhR is a cytosolic transcription factor that is normally inactive, Ahr activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae, Cd4-positive cells from mice lacking Ahr developed Th17 responses but failed to produce Il22 and did not show enhanced Th17 development, Complex assembly and ubiquitin ligase activity of CUL4B (AHR) in vitro and in vivo are dependent on the AHR ligand, Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, In the CUL4B (AHR) complex, The AHR gene is mapped on 7p21, The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival, also called bHLHe76, bound to several co-chaperones, but not in Ahr -/- mice, but were absent in Ahr -/- or Er-alpha -/- ovariectomized mice, is a member of the family of basic helix-loop-helix transcription factors, ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation, 1, AHR (aryl hydrocarbon receptor) |
| Immunogen | Amino acids DNKNNDLYNIMRNLGIDFEDIRSMQNEE of mouse AHR were used as the immunogen for the AHR antibody |
| Storage | Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the AHR antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target | Aryl Hydrocarbon Receptor / AHR |
| Short name | Aryl Hydrocarbon Receptor Antibody / AHR |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | Aryl Hydrocarbon Receptor (Antibody to) / aryl hydrocarbon receptor |
| Alternative technique | antibodies |
| Alternative to gene target | AHR and IDBG-629848 and ENSBTAG00000007746 and 280714, AHR and IDBG-8995 and ENSG00000106546 and 196, Ahr and IDBG-134957 and ENSMUSG00000019256 and 11622, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006805 and xenobiotic metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006950 and response to stress and biological process this GO :0007049 and cell cycle and biological process this GO :0007165 and signal transduction and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0009410 and response to xenobiotic stimulus and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0030522 and intracellular receptor signaling pathway and biological process this GO :0030850 and prostate gland development and biological process this GO :0030888 and regulation of B cell proliferation and biological process this GO :0032922 and circadian regulation of gene expression and biological process this GO :0034752 and cytosolic aryl hydrocarbon receptor complex and cellular component this GO :0035326 and enhancer binding and molecular function this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045899 and positive regulation of RNA polymerase II transcriptional preinitiation complex assembly and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0046983 and protein dimerization activity and molecular function this GO :0048608 and reproductive structure development and biological process this GO :0048732 and gland development and biological process this GO :0051879 and Hsp90 protein binding and molecular function this GO :0070888 and E-box binding and molecular function, E-box binding, bHLHe76, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001568 and blood vessel development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0004871: signal transducer activity and also this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0035326: enhancer binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046982: protein heterodimerization activity and also this GO :0046983: protein dimerization activity and also this GO :0051879: Hsp90 protein binding and also this GO :0070888: E-box binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0004871: signal transducer activity, this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0035326: enhancer binding, this GO :0043565: sequence-specific DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046982: protein heterodimerization activity, this GO :0046983: protein dimerization activity, this GO :0051879: Hsp90 protein binding, this GO :0070888: E-box binding, aryl hydrocarbon receptor |
| Identity | 348 |
| Gene | AHR |
| Long gene name | aryl hydrocarbon receptor |
| Synonyms | bHLHe76 |
| Locus | 7p21, 1 |
| Discovery year | 1993-05-18 |
| GenBank acession | L19872 |
| Entrez gene record | 196 |
| Pubmed identfication | 8125016 |
| RefSeq identity | NM_001621 |
| Classification | Basic helix-loop-helix proteins |
| Havana BLAST/BLAT | OTTHUMG00000149967 |
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