| Long name | ASCL1 Primary Polyclonal Antibody |
| Also known as | ASCL1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ASCL1 |
| Specificity | This is a highly specific antibody against ASCL1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 190-236/236 |
| Subcellular location | Nucleus |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ASCL1 |
| Gene ID number | 429 |
| Swiss Prot | P50553 |
| Tested Applications | IF(IHC-P), IHC-P |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, Essential for the generation of olfactory and autonomic neurons (By similarity), Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS, probably through DLL4-NOTCH signaling activation, Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG-3') |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ASCL1, ASH-1, Achaete-scute homolog 1, Class A basic helix-loop-helix protein 46, HASH1, MASH1, bHLHa46, ASH1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | ASCL1 |
| Short name | ASCL1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | achaete-scute complex homolog 1 (Drosophila) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | ASCL1 and IDBG-53767 and ENSG00000139352 and 429, ASCL1 and IDBG-648540 and ENSBTAG00000016227 and 540473, ASH1 and bHLHa46 and HASH1 and MASH1, Ascl1 and IDBG-182849 and ENSMUSG00000020052 and 17172, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0007389 and pattern specification process and biological process this GO :0007399 and nervous system development and biological process this GO :0007400 and neuroblast fate determination and biological process this GO :0007405 and neuroblast proliferation and biological process this GO :0008593 and regulation of Notch signaling pathway and biological process this GO :0010001 and glial cell differentiation and biological process this GO :0010226 and response to lithium ion and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0014003 and oli this GO dendrocyte development and biological process this GO :0021527 and spinal cord association neuron differentiation and biological process this GO :0021529 and spinal cord oli this GO dendrocyte cell differentiation and biological process this GO :0021530 and spinal cord oli this GO dendrocyte cell fate specification and biological process this GO :0021750 and vestibular nucleus development and biological process this GO :0021779 and oli this GO dendrocyte cell fate commitment and biological process this GO :0021879 and forebrain neuron differentiation and biological process this GO :0021892 and cerebral cortex GABAergic interneuron differentiation and biological process this GO :0021902 and commitment of neuronal cell to specific neuron type in forebrain and biological process this GO :0021954 and central nervous system neuron development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022008 and neurogenesis and biological process this GO :0030154 and cell differentiation and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030856 and regulation of epithelial cell differentiation and biological process this GO :0032526 and response to retinoic acid and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043425 and bHLH transcription factor binding and molecular function this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045787 and positive regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048469 and cell maturation and biological process this GO :0048485 and sympathetic nervous system development and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048665 and neuron fate specification and biological process this GO :0048666 and neuron development and biological process this GO :0048699 and generation of neurons and biological process this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0050767 and regulation of neurogenesis and biological process this GO :0050769 and positive regulation of neurogenesis and biological process this GO :0050883 and musculoskeletal movement, E-box binding, nuclei, spinal reflex action and biological process this GO :0051593 and response to folic acid and biological process this GO :0060163 and subpallium neuron fate commitment and biological process this GO :0060165 and regulation of timing of subpallium neuron differentiation and biological process this GO :0060166 and olfactory pit development and biological process this GO :0060487 and lung epithelial cell differentiation and biological process this GO :0060579 and ventral spinal cord interneuron fate commitment and biological process this GO :0061100 and lung neuroendocrine cell differentiation and biological process this GO :0061102 and stomach neuroendocrine cell differentiation and biological process this GO :0061103 and carotid body glomus cell differentiation and biological process this GO :0061104 and adrenal chromaffin cell differentiation and biological process this GO :0061549 and sympathetic ganglion development and biological process this GO :0070849 and response to epidermal growth factor and biological process this GO :0070888 and E-box binding and molecular function this GO :0071259 and cellular response to magnetism and biological process this GO :2000179 and positive regulation of neural precursor cell proliferation and biological process, this GO :0000989 and transcription factor binding transcription factor activity and molecular function this GO :0001764 and neuron migration and biological process this GO :0003358 and noradrenergic neuron development and biological process this GO :0003359 and noradrenergic neuron fate commitment and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0000989: transcription factor binding transcription factor activity, this GO :0000989: transcription factor binding transcription factor activity and also this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003690: double-stranded DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding and also this GO :0042803: protein homodimerization activity and also this GO :0043425: bHLH transcription factor binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0046983: protein dimerization activity and also this GO :0070888: E-box binding, this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003690: double-stranded DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, this GO :0042803: protein homodimerization activity, this GO :0043425: bHLH transcription factor binding, this GO :0043565: sequence-specific DNA binding, this GO :0046983: protein dimerization activity, this GO :0070888: E-box binding, achaete-scute complex homolog 1 (Drosophila) |
| Identity | 738 |
| Gene | ASCL1 |
| Long gene name | achaete-scute family bHLH transcription factor 1 |
| Synonyms gene name | achaete-scute complex (Drosophila) homolog-like 1 achaete-scute complex-like 1 (Drosophila) achaete-scute complex homolog 1 (Drosophila) |
| Synonyms | ASH1 HASH1 bHLHa46 |
| Locus | 12q23, 2 |
| Discovery year | 1993-12-09 |
| GenBank acession | L08424 |
| Entrez gene record | 429 |
| Pubmed identfication | 8390674 |
| Classification | Basic helix-loop-helix proteins |
| Havana BLAST/BLAT | OTTHUMG00000169967 |
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