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ASK1 (Thr845) Antibody

ASK1 (Thr845) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameASK1 (Thr845) Primary Polyclonal Antibody
Also known asASK1 (Thr845) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenASK1 Thr845
SpecificityThis is a highly specific antibody against ASK1 Thr845
Modification(s)Phosphorylation
Modification site(s)Thr845
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range825-875/1380
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from mouse ASK1 around the phosphorylation site of Thr845
Gene ID number26408
Swiss ProtO35099
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1), MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, MAP3K5/ASK1 is required for the innate immune response, Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, Mediates signaling for determination of cell fate such as differentiation and survival, Once activated, Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation, Plays an important role in the cascades of cellular responses evoked by changes in the environment, These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs), acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS), which is essential for host defense against a wide range of pathogens, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 742452D2Rik, ASK-1, ASK1, Apoptosis signal-regulating kinase 1, MAPK/ERK kinase kinase 5, MAPKKK5, MEK kinase 5, MEKK 5, Map3k5, Mekk5, Mitogen-activated protein kinase kinase kinase 5, ASK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetASK1 (Thr845)
Short nameASK1 (Thr845) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameASK1 (Thr845) (Antibody to)
Alternative techniqueantibodies
Identity 6857
Gene MAP3K5
Long gene name mitogen-activated protein kinase kinase kinase 5
Synonyms gene MEKK5
Synonyms MAPKKK5 ASK1
Synonyms name apoptosis signal regulating kinase 1
Locus 6q23, 3
Discovery year 1997-11-14
GenBank acession U67156
Entrez gene record 4217
Pubmed identfication 9465908
Classification Mitogen-activated protein kinase kinase kinases
Havana BLAST/BLAT OTTHUMG00000015647
Locus Specific Databases The Globin Gene Server

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