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ASK1 (Thr845) Antibody, ALEXA FLUOR 594

ASK1 (Thr845) Antibody, ALEXA FLUOR 594 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 594 Conjugated, ASK1 (Thr845) Polyclonal Antibody
Also known asAnti-ASK1 Thr845 PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated with 594, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenASK1 Thr845
SpecificityThis is a highly specific antibody against ASK1 Thr845
ModificationPhosphorylation
Modification SiteThr845
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range825-875/1380
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from mouse ASK1 around the phosphorylation site of Thr845
Gene ID Number26408
Swiss ProtO35099
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1), MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, MAP3K5/ASK1 is required for the innate immune response, Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, Mediates signaling for determination of cell fate such as differentiation and survival, Once activated, Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation, Plays an important role in the cascades of cellular responses evoked by changes in the environment, These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs), acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS), which is essential for host defense against a wide range of pathogens, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission590nm/617nm
Synonyms MAPKKK5 ASK1
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation 594, ALEXA FLUOR®, Alexa Fluor
ConjugatedAlexa conjugate 1
Gene targetASK1 (Thr845)
Short nameASK1 (Thr845) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 594
Alternative name ALEXA FLUOR 594, ASK1 (Thr845) (Antibody to)
Alternative techniqueantibodies
Identity 6857
Gene MAP3K5
Long gene name mitogen-activated protein kinase kinase kinase 5
Synonyms gene MEKK5
Synonyms name apoptosis signal regulating kinase 1
Locus 6q23, 3
Discovery year 1997-11-14
GenBank acession U67156
Entrez gene record 4217
Pubmed identfication 9465908
Classification Mitogen-activated protein kinase kinase kinases
Havana BLAST/BLAT OTTHUMG00000015647
Locus Specific Databases The Globin Gene Server

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