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ASK1 (Thr845) Antibody, Biotin Conjugated

ASK1 (Thr845) Antibody, Biotin Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, ASK1 (Thr845) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenASK1 Thr845
SpecificityThis is a highly specific antibody against ASK1 Thr845
ModificationPhosphorylation
Modification siteThr845
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range825-875/1380
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from mouse ASK1 around the phosphorylation site of Thr845
Gene ID number26408
Swiss ProtO35099
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1), MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, MAP3K5/ASK1 is required for the innate immune response, Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, Mediates signaling for determination of cell fate such as differentiation and survival, Once activated, Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation, Plays an important role in the cascades of cellular responses evoked by changes in the environment, These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs), acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS), which is essential for host defense against a wide range of pathogens, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms MAPKKK5 ASK1
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetASK1 (Thr845) Conjugated
Short name Conjugated, ASK1 (Thr845) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, ASK1 (Thr845) (Antibody to)
Alternative techniqueantibodies
Identity 6857
Gene MAP3K5
Long gene name mitogen-activated protein kinase kinase kinase 5
Synonyms gene MEKK5
Synonyms name apoptosis signal regulating kinase 1
Locus 6q23, 3
Discovery year 1997-11-14
GenBank acession U67156
Entrez gene record 4217
Pubmed identfication 9465908
Classification Mitogen-activated protein kinase kinase kinases
Havana BLAST/BLAT OTTHUMG00000015647
Locus Specific Databases The Globin Gene Server

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