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ATF1 (Ser63) Antibody, ALEXA FLUOR 350

ATF1 (Ser63) Antibody, ALEXA FLUOR 350 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, ATF1 (Ser63) Polyclonal Antibody
Also known asAnti-ATF1 Ser63 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenATF1 Ser63
SpecificityThis is a highly specific antibody against ATF1 Ser63
ModificationPhosphorylation
Modification SiteSer63
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human ATF1 around the phosphorylation site of Ser63
Gene ID Number466
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen A chimeric protein composed of the N-terminal domain of EWS (Ewing sarcoma oncogene) linked to the bZip domain of ATF1 is implicated in the rare malignant clear cell sarcoma of tendon sheath and aponeuroses (malignant melanoma of soft parts), ATF1 is a nuclear protein that binds DNA as a homodimer or as heterodimers with the inducible transcription factors CREB1 or CREM, ATF1 is detectable in metastatic melanoma cells and seems to contribute to their survival, ATF1 mediates both Ca2+ and cAMP responses at several levels, Heterodimers appear to be stronger transcriptional activators than the homodimers, It binds to the Tax-responsive element (TRE1) of the human T-cell lymphotropic virus type-I (HTLV1), Many of these genes are important in cell growth and differentiation, Several isoforms of ATF1 arise by differential splicing, TREB-36) is a member of the ATF/CREB family of basic region leucine-zipper (bZip) DNA-binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes, The activation function of CRE-binding proteins may be modulated by phosphorylation of several kinases and is mediated by coactivators such as CREB-binding protein (CBP) and p300, Tissue expression of ATF1 mRNA is widespread, and in stress and immune responses, ATF1 (Activating Transcription Factor 1
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms TREB36
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetATF1 (Ser63)
Short nameATF1 (Ser63) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, ATF1 (Ser63) (Antibody to)
Alternative techniqueantibodies
Identity 783
Gene ATF1
Long gene name activating transcription factor 1
Locus 12q13, 12
Discovery year 1994-03-16
GenBank acession BC029619
Entrez gene record 466
Pubmed identfication 8401579
RefSeq identity NM_005171
Classification Basic leucine zipper proteins
Havana BLAST/BLAT OTTHUMG00000169482

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