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ATF2 (Thr51 + Thr53) Antibody

ATF2 (Thr51 + Thr53) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameATF2 (Thr51 + Thr53) Primary Polyclonal Antibody
Also known asATF2 (Thr51 + Thr53) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenATF2 Thr51 + Thr53
SpecificityThis is a highly specific antibody against ATF2 Thr51 + Thr53
Modification(s)Phosphorylation
Modification site(s)Thr51 + Thr53
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from mouse ATF2 around the phosphorylation site of Thr51 + Thr53
Gene ID number11909
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families, ATF2 is abundantly expressed in brain, Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, It is a stronger activator as a heterodimer with cJun than as a homodimer, Many of these genes are important in cell growth and differentiation, Several isoforms of ATF2 arise by differential splicing, Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain, This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase, and UV irradiation, and in stress and immune responses, inflammatory cytokines, seemingly in a protein phosphatase-dependent mechanism, ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ATF 2, ATF2 phospho Thr51 + Thr53, ATF2 protein, ATF2_HUMAN, Atf-2, CRE BP1, CRE-BP, CREB 2, CREB 2, CREB2, CREBP1, Cyclic AMP dependent transcription factor ATF 2, Cyclic AMP-responsive, HB 16, cAMP Response Element Binding Protein 2, cAMP response element binding protein CRE BP1, cAMP-dependent transcription factor ATF-2, cAMP-responsive element-binding protein 2, p-ATF2 phospho T51 + T53, p-ATF2 phospho Thr51 + Thr53, ATF2 phospho T51 + T53, Activating Transcription Factor 2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetATF2 (Thr51 + Thr53)
Short nameATF2 (Thr51 + Thr53) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameATF2 (Thr51 and Thr53) (Antibody to)
Alternative techniqueantibodies
Identity 4232
Gene GDNF
Long gene name glial cell derived neurotrophic factor
Synonyms ATF1 ATF2 HFB1-GDNF
Synonyms name astrocyte-derived trophic factor glial cell line derived neurotrophic factor glial derived neurotrophic factor
Locus 5p13, 2
Discovery year 1995-05-04
Entrez gene record 2668
Pubmed identfication 8493557
RefSeq identity NM_000514
Classification Endogenous ligands
Havana BLAST/BLAT OTTHUMG00000090809

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