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ATF4/CREB-2 Antibody

ATF4/CREB-2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameATF4/CREB-2 Primary Polyclonal Antibody
Also known asATF4/CREB-2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenATF4/CREB-2
SpecificityThis is a highly specific antibody against ATF4/CREB-2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range240-290/351
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ATF4
Gene ID number468
Swiss ProtP18848
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activates transcription of SIRT4, Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes, Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity), In concert with DDIT3/CHOP, It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I, Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4, Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress, a sequence present in many viral and cellular promoters, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA, Transcriptional activator
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ATF4, Activating transcription factor 4, CREB-2, Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, TAXREB67, TXREB, Tax-responsive enhancer element-binding protein 67, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, CREB2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetATF4/CREB-2
Short nameATF4/CREB-2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameATF4/CREB-2 (Antibody to)
Alternative techniqueantibodies
Identity 786
Gene ATF4
Long gene name activating transcription factor 4
Synonyms gene TXREB
Synonyms gene name activating transcription factor 4 (tax-responsive enhancer element B67)
Synonyms TAXREB67 CREB-2
Synonyms name tax-responsive enhancer element B67
Locus 22q13, 1
Discovery year 1992-06-09
GenBank acession D90209
Entrez gene record 468
Pubmed identfication 1847461 1534408
RefSeq identity NM_001675
Classification Basic leucine zipper proteins
Havana BLAST/BLAT OTTHUMG00000151099

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