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ATG3 (1377CT239.6.1.12) Monoclonal Antibody

ATG3 (1377CT239.6.1.12) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name1, 12) Monoclonal Antibody, 6, ATG3 (1377CT239
Also known as1, 12) Monoclonal Antibody, 6, ATG3 (1377CT239
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenATG3
SpecificityThis is a highly specific antibody against ATG3
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1, 1377CT239, 6, 12
SourceThis ATG3 antibody is generated from a mouse immunized with recombinant protein of human ATG3
Gene ID number64422
Swiss ProtQ9NT62
Tested ApplicationsIHC-P
Recommended dilutions IHC-P(1:25), IHC-P(1:25)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy, ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3, Also acts as an autocatalytic E2-like enzyme, GABARAPL1, GABARAPL2 or MAP1LC3A), Preferred substrate is MAP1LC3A, Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway, Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE), The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt), This step is required for the membrane association of ATG8-like proteins, and mitochondrial homeostasis, autophagy, catalyzing the conjugation of ATG12 to itself, E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt)
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names APG3-LIKE, APG3L, ATG3, Autophagy-related protein 3, PC3-96, Protein PC3-96, Ubiquitin-like-conjugating enzyme ATG3, hApg3, APG3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target1, 12) Monoclonal, 6, ATG3 (1377CT239
Short name1, 12) Monoclonal Antibody, 6, ATG3 (1377CT239
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name1, 12) monoclonal (Antibody to), 6, autophagy related 3 (1377CT239
Alternative techniqueantibodies
Alternative to gene target ATG3 and IDBG-49891 and ENSG00000144848 and 64422, ATG3 and IDBG-632300 and ENSBTAG00000009084 and 508571, Atg3 and IDBG-162821 and ENSMUSG00000022663 and 67841, Cytoplasm, enzyme binding, this GO :0000045 and autophagic vacuole assembly and biological process this GO :0000153 and cytoplasmic ubiquitin ligase complex and cellular component this GO :0000422 and mitochondrion degradation and biological process this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006464 and cellular protein modification process and biological process this GO :0006612 and protein targeting to membrane and biological process this GO :0006914 and autophagy and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019776 and Atg8 ligase activity and molecular function this GO :0019777 and Atg12 ligase activity and molecular function this GO :0019787 and small conjugating protein ligase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0044804 and nucleophagy and biological process this GO :1902017 and regulation of cilium assembly and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0019776: Atg8 ligase activity and also this GO :0019777: Atg12 ligase activity and also this GO :0019787: small conjugating protein ligase activity and also this GO :0019899: enzyme binding, this GO :0019776: Atg8 ligase activity, this GO :0019777: Atg12 ligase activity, this GO :0019787: small conjugating protein ligase activity, this GO :0019899: enzyme binding, autophagy related 3
Identity 20962
Gene ATG3
Long gene name autophagy related 3
Synonyms gene APG3L
Synonyms gene name APG3 autophagy 3-like (S, cerevisiae) , cerevisiae) ATG3 autophagy related 3 homolog (S
Synonyms PC3-96 FLJ22125 MGC15201 DKFZp564M1178
Locus 3q13, 2
Discovery year 2004-07-05
Entrez gene record 64422
Pubmed identfication 11825910
RefSeq identity NM_022488
Classification Autophagy related
Havana BLAST/BLAT OTTHUMG00000159260

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