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Aurora A+B+C Antibody, ALEXA FLUOR 488

Aurora A+B+C Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, Aurora A+B+C Polyclonal Antibody
Also known asAnti-Aurora A+B+C PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAurora A+B+C
SpecificityThis is a highly specific antibody against Aurora A+B+C
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range70-105/344
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Aurora B
Gene ID Number9212
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen A positive feedback between GSG2 and AURKB contributes to CPC localization, A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres, AURKB is also required for kinetochore localization of BUB1 and SGOL1, AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP, DES/desmin, GPAF, GSG2/Haspin, Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis, KIF2C, Key component of the cytokinesis checkpoint, Key regulator of active promoters in resting B- and T-lymphocytes, NSUN2, Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, Phosphorylation of INCENP leads to increased AURKB activity, Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, Phosphorylation of p53/TP53 negatively regulates its transcriptional activity, PubMed:24814515), RACGAP1, Required for central/midzone spindle assembly and cleavage furrow formation, SEPT1, The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly, VIM/vimentin, a complex that acts as a key regulator of mitosis, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, and histone H3, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, respectively), whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms AIM-1, ARK-1, ARK-2, ARK-3, Aurora 1, Aurora 3, Aurora kinase B, Aurora kinase C, Aurora- and IPL1-like midbody-associated protein 1, Aurora-related kinase 1, Aurora-related kinase 2, Aurora-related kinase 3, Aurora/IPL1-related kinase 1, Aurora/IPL1-related kinase 2, Aurora/IPL1-related kinase 3, Aurora/IPL1/Eg2 protein 2, Breast tumor-amplified kinase, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase aurora-B, Serine/threonine-protein kinase aurora-C, hARK1, Aurora 2
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Aurora A+B+C Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetAurora A+B+C
Short nameAurora A+B+C Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, Aurora A+B+C (Antibody to)
Alternative techniqueantibodies

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