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Aurora A+B+C Antibody, FITC Conjugated

Aurora A+B+C Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, Aurora A+B+C Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAurora A+B+C
SpecificityThis is a highly specific antibody against Aurora A+B+C
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range70-105/344
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human Aurora B
Gene ID number9212
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background A positive feedback between GSG2 and AURKB contributes to CPC localization, A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres, AURKB is also required for kinetochore localization of BUB1 and SGOL1, AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP, DES/desmin, GPAF, GSG2/Haspin, Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis, KIF2C, Key component of the cytokinesis checkpoint, Key regulator of active promoters in resting B- and T-lymphocytes, NSUN2, Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, Phosphorylation of INCENP leads to increased AURKB activity, Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, Phosphorylation of p53/TP53 negatively regulates its transcriptional activity, PubMed:24814515), RACGAP1, Required for central/midzone spindle assembly and cleavage furrow formation, SEPT1, The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly, VIM/vimentin, a complex that acts as a key regulator of mitosis, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, and histone H3, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, respectively), whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms AIM-1, ARK-1, ARK-2, ARK-3, Aurora 1, Aurora 3, Aurora kinase B, Aurora kinase C, Aurora- and IPL1-like midbody-associated protein 1, Aurora-related kinase 1, Aurora-related kinase 2, Aurora-related kinase 3, Aurora/IPL1-related kinase 1, Aurora/IPL1-related kinase 2, Aurora/IPL1-related kinase 3, Aurora/IPL1/Eg2 protein 2, Breast tumor-amplified kinase, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase aurora-B, Serine/threonine-protein kinase aurora-C, hARK1, Aurora 2
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetAurora A+B+C Conjugated
Short name FITC Conjugated, Aurora A+B+C Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, Aurora A+B+C (Antibody to)
Alternative techniqueantibodies

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