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Aurora B (AF7B11) Monoclonal Antibody

Aurora B (AF7B11) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAurora B (AF7B11) Monoclonal Antibody
Also known asAurora B (AF7B11) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAurora B
SpecificityThis is a highly specific antibody against Aurora B
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone numberAF7B11
Concentration2ug/ul
SourceRecombinant human protein purified from E, coli (His-Aurora B)
Gene ID number9212
Swiss ProtQ96GD4
Tested ApplicationsWB
Recommended dilutions0 ug/mL), WB (2
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A positive feedback between GSG2 and AURKB contributes to CPC localization, A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres, AURKB is also required for kinetochore localization of BUB1 and SGO1, AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP, DES/desmin, GPAF, GSG2/Haspin, Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis, KIF2C, Key component of the cytokinesis checkpoint, NSUN2, Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, Phosphorylation of INCENP leads to increased AURKB activity, Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, Phosphorylation of p53/TP53 negatively regulates its transcriptional activity, PubMed:24814515), RACGAP1, Required for central/midzone spindle assembly and cleavage furrow formation, SEPT1, The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly, VIM/vimentin, a complex that acts as a key regulator of mitosis, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, and histone H3, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, respectively), whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC)
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AIM-1, AIM1, AIRK2, ARK-2, ARK2, AURKB, AurB, Aurora 1, Aurora kinase B, Aurora- and IPL1-like midbody-associated protein 1, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, IPL1, PPP1R48, STK-1, STK1, STK12, STK5, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, aurkb-sv1, aurkb-sv2, AIK2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetAurora B (AF7B11) Monoclonal
Short nameAurora B (AF7B11) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameAurora B (AF7B11) monoclonal (Antibody to)
Alternative techniqueantibodies

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