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Aurora B Antibody

Aurora B Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenAurora B
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Primate, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the Aurora B antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis Aurora B antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q96GD4
PurityPurified
Description A positive feedback between GSG2 and AURKB contributes to CPC localization, A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres, AURKB is also required for kinetochore localization of BUB1 and SGOL1, AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP, DES/desmin, GPAF, GSG2/Haspin, Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis, KIF2C, Key component of the cytokinesis checkpoint, Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, NSUN2, Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, Phosphorylation of INCENP leads to increased AURKB activity, Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, Phosphorylation of p53/TP53 negatively regulates its transcriptional activity, RACGAP1, Required for central/midzone spindle assembly and cleavage furrow formation, SEPT1, The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly, VIM/vimentin, [UniProt], a complex that acts as a key regulator of mitosis, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, and histone H3, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis, respectively), whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC)
ImmunogenA portion of amino acids 6-35 from the human protein was used as the immunogen for this Aurora B antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Aurora B antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetAurora B
Short nameAurora B Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAurora B (Antibody to)
Alternative techniqueantibodies

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