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AXL Antibody, ALEXA FLUOR 555

AXL Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, AXL Polyclonal Antibody
Also known asAnti-AXL PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAXL
SpecificityThis is a highly specific antibody against AXL
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range180-230/894
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AXL
Gene ID Number558
Swiss ProtP30530
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, Following activation by ligand, GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, In case of filovirus infection, LCK and PTPN11, Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL, NCK2, Other downstream substrate candidates for AXL are CBL, PIK3R2 and PIK3R3, PLCG1, Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response, Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase, SOCS1 and TENC1, but also GRB2, cell proliferation, gonadotropin-releasing hormone neuron survival and migration, hepatic regeneration, migration and differentiation, optimal cytokine signaling during human natural killer cell development, or regulation of thrombotic responses, platelet activation, seems to function as a cell entry factor, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms UFO JTK11 Tyro7 ARK
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetAXL
Short nameAXL Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, AXL (Antibody to)
Alternative techniqueantibodies
Identity 905
Gene AXL
Long gene name AXL receptor tyrosine kinase
Locus 19q13, 2
Discovery year 1992-09-15
GenBank acession M76125
Entrez gene record 558
Pubmed identfication 1656220
Classification Immunoglobulin like domain containing V-set domain containing Fibronectin type III domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000182727

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