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AXL Antibody, FITC Conjugated

AXL Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, AXL Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAXL
SpecificityThis is a highly specific antibody against AXL
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range180-230/894
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human AXL
Gene ID number558
Swiss ProtP30530
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, Following activation by ligand, GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, In case of filovirus infection, LCK and PTPN11, Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL, NCK2, Other downstream substrate candidates for AXL are CBL, PIK3R2 and PIK3R3, PLCG1, Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response, Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase, SOCS1 and TENC1, but also GRB2, cell proliferation, gonadotropin-releasing hormone neuron survival and migration, hepatic regeneration, migration and differentiation, optimal cytokine signaling during human natural killer cell development, or regulation of thrombotic responses, platelet activation, seems to function as a cell entry factor, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms UFO JTK11 Tyro7 ARK
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetAXL Conjugated
Short name FITC Conjugated, AXL Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, AXL (Antibody to)
Alternative techniqueantibodies
Identity 905
Gene AXL
Long gene name AXL receptor tyrosine kinase
Locus 19q13, 2
Discovery year 1992-09-15
GenBank acession M76125
Entrez gene record 558
Pubmed identfication 1656220
Classification Immunoglobulin like domain containing V-set domain containing Fibronectin type III domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000182727

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