Filters

AZIN2 Antibody / Antizyme inhibitor 2

AZIN2 Antibody / Antizyme inhibitor 2 size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenAZIN2 / Antizyme inhibitor 2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions5-1ug/ml, IHC (FFPE): 1-2ug/ml, Western blot: 0
Added buffer025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2
Intented useThis AZIN2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q96A70
PurityAntigen affinity
Description AZIN2 interacts with all three antizymes and stimulates ODC activity and polyamine uptake, AZIN2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment, Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect, Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, However, Like AZIN1, Recent studies indicate that AZIN2 is also expressed in specific cell types in ovaries, The exact function of this gene is not known, The protein encoded by this gene belongs to the antizyme inhibitor family, This gene encodes antizyme inhibitor 2, adrenal glands and pancreas, also known as arginine decarboxylase (ADC), and in mast cells, as well as by inhibiting polyamine uptake, available data suggest its role in cell growth, however, however, is an enzyme that in humans is encoded by the AZIN2 gene, retain the ability to bind to antizymes, spermiogenesis, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, the second member of this gene family, unlike AZIN1, vesicular trafficking and secretion, which is ubiquitously expressed and localized in the nucleus and cytoplasm, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell, Antizyme inhibitor 2 (AzI2)
ImmunogenAmino acids C111-Q301 from the human protein were used as the immunogen for the AZIN2 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the AZIN2 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
Localization possible cytoplasmic staining, Predominantly nuclear
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetAZIN2 / Antizyme inhibitor 2
Short nameAZIN2 Antibody / Antizyme inhibitor 2
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAZIN2 (Antibody to) / Antizyme suppressor 2
Alternative techniqueantibodies
Identity 29957
Gene AZIN2
Long gene name antizyme inhibitor 2
Synonyms gene ADC
Synonyms gene name arginine decarboxylase
Synonyms ODC-p ODC1L KIAA1945 ODCp
Synonyms name ornithine decarboxylase like
Locus 1p35, 1
Discovery year 2005-06-06
GenBank acession AY050635
Entrez gene record 113451
Pubmed identfication 11587527 14738999 17900240
Havana BLAST/BLAT OTTHUMG00000004130

Similar products

Subscribe to our Newsletter