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Bad (Ser118) Antibody, Biotin Conjugated

Bad (Ser118) Antibody, Biotin Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, Bad (Ser118) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBad Ser118
SpecificityThis is a highly specific antibody against Bad Ser118
ModificationPhosphorylation
Modification siteSer118
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human BAD around the phosphorylation site of Ser118
Gene ID number572
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Alternative splicing of this gene results in two transcript variants which encode the same isoform, Bad is found on the outer mitochondrial membrane and, Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins, JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis, The latter interaction is critical for Bad phosphorylation at serine 155, The phosphorylation status of Bad represents a key checkpoint for death or cell survival, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival, once phosphorylated in response to growth stimuli, thus preventing them from binding with BAX, translocates to the cytoplasm, Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms BBC 2, BBC2, BBC6, BCL X / BCL 2 Binding Protein, Bad phospho Ser118, Bcl 2 Antagonist of Cell Death, Bcl 2 Binding Component 6, mouse BAD Ser155, p-Bad S118, p-Bad phospho Ser118, rat BAD Ser156, Bad phospho S118, p- Bad Ser118
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetBad (Ser118) Conjugated
Short name Conjugated, Bad (Ser118) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, BCL2-associated a this GO nist on cell death (Ser118) (Antibody to)
Alternative techniqueantibodies

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