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BAP1 (Ser592) Antibody, Cy7 Conjugated

BAP1 (Ser592) Antibody, Cy7 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, BAP1 (Ser592) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBAP1 Ser592
Specificity This phosphorylation site is homologous to the Ser590 site in Rat, This is a highly specific antibody against BAP1 Ser592
ModificationPhosphorylation
Modification siteSer592
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range570-620/729
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592
Gene ID number8314
Swiss ProtQ92560
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, Acts as a tumor suppressor, Catalytic component of the PR-DUB complex, Deubiquitination of HCFC1 does not lead to increase stability of HCFC1, Does not deubiquitinate monoubiquitinated histone H2B, Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination, It however does not mediate deubiquitination of BRCA1 and BARD1, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1), thereby protecting it from cytoplasmic sequestration (PubMed:24703950), with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains, Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms hucep-6 KIAA0272 UCHL2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetBAP1 (Ser592) Conjugated
Short name Conjugated, BAP1 (Ser592) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, BAP1 (Ser592) (Antibody to)
Alternative techniqueantibodies
Identity 950
Gene BAP1
Long gene name BRCA1 associated protein 1
Synonyms gene name BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Synonyms name ubiquitin carboxy-terminal hydrolase
Locus 3p21, 1
Discovery year 1998-09-17
GenBank acession AF045581
Entrez gene record 8314
Pubmed identfication 9528852
Classification Ubiquitin C-terminal hydrolases
Havana BLAST/BLAT OTTHUMG00000158392
Locus Specific Databases LRG_529

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