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BCAR1 (Tyr249) Antibody, FITC Conjugated

BCAR1 (Tyr249) Antibody, FITC Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, BCAR1 (Tyr249) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBCAR1 Tyr249
SpecificityThis is a highly specific antibody against BCAR1 Tyr249
ModificationPhosphorylation
Modification siteTyr249
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human BCAR1 around the phosphorylation site of Tyr249
Gene ID number9564
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background By immunoprecipitation analysis, One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk, p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins, suggesting a role in v-Crk-mediated cell signaling, which in turn phosphorylates p130 Cas, p130 represents one of several known substrates for v-Crk encoded p47
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms P130Cas Crkas CAS CASS1
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetBCAR1 (Tyr249) Conjugated
Short name FITC Conjugated, BCAR1 (Tyr249) Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, breast cancer antibody to-estrogen resistance 1 (Tyr249) (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BCAR1 and IDBG-42468 and ENSG00000050820 and 9564, BCAR1 and IDBG-629067 and ENSBTAG00000012002 and, Bcar1 and IDBG-193577 and ENSMUSG00000031955 and 12927, CAS and CAS1 and CASS1 and CRKAS and P130Cas, nuclei, protein kinase binding, this GO :0001558 and regulation of cell growth and biological process this GO :0001726 and ruffle and cellular component this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007596 and blood coagulation and biological process this GO :0008283 and cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0010595 and positive regulation of endothelial cell migration and biological process this GO :0016477 and cell migration and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030168 and platelet activation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0035729 and cellular response to hepatocyte growth factor stimulus and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0048010 and vascular endothelial growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048012 and hepatocyte growth factor receptor signaling pathway and biological process this GO :0050851 and antigen receptor-mediated signaling pathway and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051301 and cell division and biological process this GO :0060326 and cell chemotaxis and biological process, this GO :0004871: signal transducer activity, this GO :0004871: signal transducer activity and also this GO :0005515: protein binding and also this GO :0017124: SH3 domain binding and also this GO :0019901: protein kinase binding, this GO :0005515: protein binding, this GO :0017124: SH3 domain binding, this GO :0019901: protein kinase binding, breast cancer anti-estrogen resistance 1
Identity 971
Gene BCAR1
Long gene name BCAR1, Cas family scaffolding protein
Synonyms gene name breast cancer anti-estrogen resistance 1
Synonyms name Crk-associated substrate Cas scaffolding protein family member 1
Locus 16q23, 1
Discovery year 1999-04-29
GenBank acession AJ242987
Entrez gene record 9564
Pubmed identfication 8413311 10639512
RefSeq identity NM_014567
Classification Cas scaffolding proteins
Havana BLAST/BLAT OTTHUMG00000137604

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