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Bcl6 Antibody, ALEXA FLUOR 555

Bcl6 Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, Bcl6 Polyclonal Antibody
Also known asAnti-Bcl6 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBcl6
SpecificityThis is a highly specific antibody against Bcl6
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range520-560/706
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Bcl6
Gene ID Number604
Swiss ProtP41182
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Also required for the establishment and maintenance of immunological memory for both T- and B-cells, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, Besides, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, In GC B-cells, In follicular helper CD4(+) T-cells (T(FH) cells), In response to genotoxic stress, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, T(H)2 and T(H)17 cells, also autoregulates its transcriptional expression and up-regulates, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, apoptosis and cell cycle control, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation, indirectly, inflammation, like miR155, promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, represses genes that function in differentiation, such as AICDA, such as CCL2 and CCND2, such as HES5, the expression of some genes important for GC reactions, through the repression of microRNAs expression, Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms FLJ39821
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetBcl6
Short nameBcl6 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, B-cell CLL/lymphoma 6 (Antibody to)
Alternative techniqueantibodies
Identity 23953
Gene BCORP1
Long gene name BCL6 corepressor pseudogene 1
Synonyms gene BCORL2
Synonyms gene name BCL6 co-repressor-like 2 BCL6 corepressor-like 2
Locus Yq11, 222
Discovery year 2004-07-27
GenBank acession AK097140
Entrez gene record 286554
RefSeq identity NM_173700
Havana BLAST/BLAT OTTHUMG00000036498

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