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Bcl6 Antibody, Biotin Conjugated

Bcl6 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, Bcl6 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBcl6
SpecificityThis is a highly specific antibody against Bcl6
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range520-560/706
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human Bcl6
Gene ID number604
Swiss ProtP41182
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Also required for the establishment and maintenance of immunological memory for both T- and B-cells, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, Besides, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, In GC B-cells, In follicular helper CD4(+) T-cells (T(FH) cells), In response to genotoxic stress, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, T(H)2 and T(H)17 cells, also autoregulates its transcriptional expression and up-regulates, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, apoptosis and cell cycle control, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation, indirectly, inflammation, like miR155, promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, represses genes that function in differentiation, such as AICDA, such as CCL2 and CCND2, such as HES5, the expression of some genes important for GC reactions, through the repression of microRNAs expression, Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-5, BCL-6, BCL6, BCL6A, LAZ3, Protein LAZ-3, ZBTB27, ZNF51, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, BCL5
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetBcl6 Conjugated
Short name Conjugated, Bcl6 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, B-cell CLL/lymphoma 6 (Antibody to)
Alternative techniqueantibodies

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