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beta-Arrestin 1(Ser412) Antibody, Biotin Conjugated

beta-Arrestin 1(Ser412) Antibody, Biotin Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, beta-Arrestin 1(Ser412) Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target Antigenbeta-Arrestin 1Ser412
SpecificityThis is a highly specific antibody against beta-Arrestin 1Ser412
ModificationPhosphorylation
Modification siteSer412
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412
Gene ID number408
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background After binding to their ligand and interacting with heterotrimeric G proteins, Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs, Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane, ERK1 and 2 signaling pathway, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues, It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, Raf, Serine 412 is then dephosphorylated and the GPCRs are internalized, Serving as an adaptor or scaffold molecule, beta 2 adrenergic receptor), beta Arrestin 1 is essential for mitogenic signaling, e, leading to activation of the Ras, Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system, g
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms ARB 1, ARB1, ARR 1, ARR1, ARRB 1, ARRB1, Arrestin beta 1, p-beta Arrestin 1 phospho S412, beta Arrestin 1 phospho S412
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetbeta-Arrestin 1(Ser412) Conjugated
Short name Conjugated, beta-Arrestin 1(Ser412) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, b-Arrestin 1(Ser412) (Antibody to)
Alternative techniqueantibodies

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