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beta-Arrestin 1(Ser412) Antibody, Cy5 Conjugated

beta-Arrestin 1(Ser412) Antibody, Cy5 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5 Conjugated, beta-Arrestin 1(Ser412) Antibody
CategoryConjugated Primary Antibodies
Conjugation5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target Antigenbeta-Arrestin 1Ser412
SpecificityThis is a highly specific antibody against beta-Arrestin 1Ser412
ModificationPhosphorylation
Modification siteSer412
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412
Gene ID number408
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background After binding to their ligand and interacting with heterotrimeric G proteins, Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs, Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane, ERK1 and 2 signaling pathway, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues, It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, Raf, Serine 412 is then dephosphorylated and the GPCRs are internalized, Serving as an adaptor or scaffold molecule, beta 2 adrenergic receptor), beta Arrestin 1 is essential for mitogenic signaling, e, leading to activation of the Ras, Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system, g
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission625, 650nm/670nm
Synonyms ARB 1, ARB1, ARR 1, ARR1, ARRB 1, ARRB1, Arrestin beta 1, p-beta Arrestin 1 phospho S412, beta Arrestin 1 phospho S412
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetbeta-Arrestin 1(Ser412) Conjugated
Short name Conjugated, beta-Arrestin 1(Ser412) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy5
Alternative name cyanine 5 coupled, b-Arrestin 1(Ser412) (Antibody to)
Alternative techniqueantibodies

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