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Beta-Catenin (Ser552) Antibody

Beta-Catenin (Ser552) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameBeta-Catenin (Ser552) Antibody
Also known asBeta-Catenin (Ser552) Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenBeta-Catenin Ser552
Specificity This phosphorylation site is homologous in the listed cross reactive species at the specified location, This is a highly specific antibody against Beta-Catenin Ser552
Modification(s)Phosphorylation
Modification site(s)Ser552
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range530-570/781
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human Beta-Catenin around the phosphorylation site of Ser552
Gene ID number1499
Swiss ProtP35222
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen APC, AXIN2, Acts as a negative regulator of centrosome cohesion, Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome, CTNNB1 is not ubiquitinated and accumulates in the nucleus, Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, In the absence of Wnt, In the presence of Wnt ligand, Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization, Involved in the regulation of cell adhesion, Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity), PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184), PubMed:22647378, PubMed:22699938, forms a complex with AXIN1, leading to activate Wnt responsive genes, where it acts as a coactivator for transcription factors of the TCF/LEF family, Key downstream component of the canonical Wnt signaling pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Beta-catenin, CTNNB1, Catenin beta-1, MRD19, OK/SW-cl, PRO2286, armadillo, 35, CTNNB
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetBeta-Catenin (Ser552)
Short nameBeta-Catenin (Ser552) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameb-Catenin (Ser552) (Antibody to)
Alternative techniqueantibodies

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