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Bim Antibody

Bim Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenBim
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the Bim antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis Bim antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O43521
PurityPurified
Description BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities, BCL2L1/BCL-X(L), Bim contains a Bcl-2 homology domain 3 (BH3), It has been shown to interact with other members of the BCL-2 protein family, The expression of this gene can be induced by nerve growth factor (NGF), Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection, and MCL1, and to act as an apoptotic activator, as well as by the forkhead transcription factor FKHR-L1, including BCL2, which suggests a role of this gene in neuronal and lymphocyte apoptosis, Bim belongs to the BCL-2 protein family
ImmunogenA portion of amino acids 130-165 from the human protein was used as the immunogen for this Bim antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Bim antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetBim
Short nameBim Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameBim (Antibody to)
Alternative techniqueantibodies
Identity 994
Gene BCL2L11
Long gene name BCL2 like 11
Synonyms gene name BCL2-like 11 (apoptosis facilitator)
Synonyms BOD BimL BimEL BimS BIM
Locus 2q13
Discovery year 1999-12-10
GenBank acession AF032458
Entrez gene record 10018
Pubmed identfication 9731710 9430630
Classification BCL2 homology region 3 (BH3) only
Havana BLAST/BLAT OTTHUMG00000131256
Locus Specific Databases LRG_620

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