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BiP Antibody GRP78

BiP Antibody GRP78 size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenBiP GRP78
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ICC, IHC-F, IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Frozen): 0, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0
Notes Titration of the BiP antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points
Intented useThis BiP antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P11021
PurityAntigen affinity
Description 78kD(GRP78) or BiP, Shen et al, The findings ofShen et al, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by theproteasome, is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum, (2002)concluded thatBiPretains ATF6 in the ER by inhibiting its Golgi localization signals and that dissociation ofBiPduring ER stress allows ATF6 to be transported to the Golgi, (2002)demonstrated thatthe proteinis a key element in sensing the folding capacity within the ER, BiP is an essential component of the translocation machinery, HSPA5 (heat shock 70kDa protein 5) also known as glucose-regulated protein
Immunogen mouse and rat), An amino acid sequence from the C-terminus of human GRP78/BiP (EWLESHQDADIEDFK) was used as the immunogen for this BiP antibody (100% homologous in human
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the BiP antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetBiP GRP78
Short nameBiP Antibody GRP78
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameBiP (Antibody to) GRP78
Alternative techniqueantibodies
Identity 5238
Gene HSPA5
Long gene name heat shock protein family A (Hsp70) member 5
Synonyms gene GRP78
Synonyms gene name 78kD) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) , heat shock 70kD protein 5 (glucose-regulated protein
Synonyms BiP
Synonyms name 78kDa , glucose-regulated protein
Locus 9q33, 3
Discovery year 1991-07-26
Entrez gene record 3309
Classification Heat shock 70kDa proteins
Havana BLAST/BLAT OTTHUMG00000020672

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