| Long name | Cy5, 5 Conjugated, BRCA1 (Ser1466) Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | Cy5, 5, 5, Cy5 |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | BRCA1 Ser1466 |
| Specificity | This is a highly specific antibody against BRCA1 Ser1466 |
| Modification | Phosphorylation |
| Modification site | Ser1466 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1466 |
| Gene ID number | 672 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | A related pseudogene, Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene, DNA damage sensors, DNA repair of double-stranded breaks, Many alternatively spliced transcript variants, May 2009], Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers, The encoded protein combines with other tumor suppressors, This gene product associates with RNA polymerase II, This protein thus plays a role in transcription, [provided by RefSeq, also interacts with histone deacetylase complexes, and it also acts as a tumor suppressor, and recombination, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC), and through the C-terminal domain, but the full-length natures of only some of these variants has been described, has been identified, have been described for this gene, some of which are disease-associated mutations, which is also located on chromosome 17, This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | 675nm/694nm |
| Synonyms | RNF53 BRCC1 PPP1R53 FANCS |
| Properties | Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated | These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target | BRCA1 (Ser1466) Conjugated |
| Short name | Conjugated, BRCA1 (Ser1466) Antibody |
| Technique | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | 5, Cy5 |
| Alternative name | cyanine 5, early onset (Ser1466) (Antibody to), 5 coupled, breast cancer 1 |
| Alternative technique | antibodies |
| Alternative to gene target | BRCA1 and IDBG-52172 and ENSG00000012048 and 672, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046600 and negative regulation of centriole replication and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050681 and androgen receptor binding and molecular function this GO :0051571 and positive regulation of histone H3-K4 methylation and biological process this GO :0051572 and negative regulation of histone H3-K4 methylation and biological process this GO :0051573 and negative regulation of histone H3-K9 methylation and biological process this GO :0051574 and positive regulation of histone H3-K9 methylation and biological process this GO :0051865 and protein autoubiquitination and biological process this GO :0070512 and positive regulation of histone H4-K20 methylation and biological process this GO :0070531 and BRCA1-A complex and cellular component this GO :0071158 and positive regulation of cell cycle arrest and biological process this GO :0071681 and cellular response to indole-3-methanol and biological process this GO :0085020 and protein K6-linked ubiquitination and biological process this GO :2000145 and regulation of cell motility and biological process this GO :2000617 and positive regulation of histone H3-K9 acetylation and biological process this GO :2000620 and positive regulation of histone H4-K16 acetylation and biological process, androgen receptor binding, early onset, nuclei, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and biological process this GO :0007059 and chromosome segregation and biological process this GO :0007098 and centrosome cycle and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008274 and gamma-tubulin ring complex and cellular component this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009048 and dosage compensation by inactivation of X chromosome and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0015631 and tubulin binding and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0030529 and ribonucleoprotein complex and cellular component this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031436 and BRCA1-BARD1 complex and cellular component this GO :0031572 and G2 DNA damage checkpoint and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031941 and filamentous actin and cellular component this GO :0034446 and substrate adhesion-dependent cell spreading and biological process this GO :0035066 and positive regulation of histone acetylation and biological process this GO :0035067 and negative regulation of histone acetylation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043009 and chordate embryonic development and biological process this GO :0043234 and protein complex and cellular component this GO :0043627 and response to estrogen and biological process this GO :0044030 and regulation of DNA methylation and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045717 and negative regulation of fatty acid biosynthetic process and biological process this GO :0045739 and positive regulation of DNA repair and biological process this GO :0045892 and negative regulation of transcription, this GO :0000151 and ubiquitin ligase complex and cellular component this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0000793 and condensed chromosome and cellular component this GO :0000794 and condensed nuclear chromosome and cellular component this GO :0001726 and ruffle and cellular component this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0003723 and RNA binding and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005694 and chromosome and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006260 and DNA replication and biological process this GO :0006281 and DNA repair and biological process this GO :0006301 and postreplication repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006349 and regulation of gene expression by genetic imprinting and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006359 and regulation of transcription from RNA polymerase III promoter and biological process this GO :0006633 and fatty acid biosynthetic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006978 and DNA damage response, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003684: damaged DNA binding and also this GO :0003713: transcription coactivator activity and also this GO :0003723: RNA binding and also this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0015631: tubulin binding and also this GO :0016874: ligase activity and also this GO :0019899: enzyme binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046872: metal ion binding and also this GO :0050681: androgen receptor binding, this GO :0003684: damaged DNA binding, this GO :0003713: transcription coactivator activity, this GO :0003723: RNA binding, this GO :0004842: ubiquitin-protein transferase activity, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0015631: tubulin binding, this GO :0016874: ligase activity, this GO :0019899: enzyme binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046872: metal ion binding, this GO :0050681: androgen receptor binding, breast cancer 1 |
| Identity | 1100 |
| Gene | BRCA1 |
| Long gene name | BRCA1, DNA repair associated |
| Synonyms gene name | breast cancer 1, early onset breast cancer 1 |
| Synonyms name | BRCA1/BRCA2-containing complex, complementation group S , regulatory subunit 53 Fanconi anemia, subunit 1 protein phosphatase 1 |
| Locus | 17q21, 31 |
| Discovery year | 1991-02-20 |
| GenBank acession | U14680 |
| Entrez gene record | 672 |
| Pubmed identfication | 1676470 25472942 |
| RefSeq identity | NM_007294 |
| Classification | Ring finger proteins Protein phosphatase 1 regulatory subunits BRCA1 A complex BRCA1 B complex BRCA1 C complex Fanconi anemia complementation groups |
| Havana BLAST/BLAT | OTTHUMG00000157426 |
| Locus Specific Databases | Breast Cancer BRCA1 database at LOVD-China LOVD - Leiden Open Variation Database LOVD - Leiden Open Variation Database LRG_292 |
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