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BRCC36 Antibody, Biotin Conjugated

BRCC36 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, BRCC36 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBRCC36
SpecificityThis is a highly specific antibody against BRCC36
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human BRCC3/BRCC36
Gene ID number79184
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Catalytic subunit of the BRISC complex, Component of the BRCA1-A complex, Does not have activity toward 'Lys-48'-linked polyubiquitin chains, In the BRCA1-A complex, Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs), it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs), via the interaction of the BRISC complex with the CSN complex, Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms C6, 1A BRCC36
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetBRCC36 Conjugated
Short name Conjugated, BRCC36 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, BRCC36 (Antibody to)
Alternative techniqueantibodies
Identity 24185
Gene BRCC3
Long gene name BRCA1/BRCA2-containing complex subunit 3
Synonyms gene CXorf53
Synonyms gene name chromosome X open reading frame 53 BRCA1/BRCA2-containing complex, subunit 3
Synonyms name Lys-63-specific deubiquitinase
Locus Xq28
Discovery year 2004-12-03
GenBank acession X64643
Entrez gene record 79184
Pubmed identfication 1303175 14636569
RefSeq identity NM_024332
Classification BRISC complex BRCA1 A complex
Havana BLAST/BLAT OTTHUMG00000022658

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