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BRCC45 Antibody, FITC Conjugated

BRCC45 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, BRCC45 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBRCC45
SpecificityThis is a highly specific antibody against BRCC45
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human BRCC45
Gene ID number9577
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background At least three isoforms of BRCC45 are known to exist, BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway, Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36, This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage, suggesting that BRCC45 may promote tumorigenesis when overexpressed, BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms BRCC45 BRCC4
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetBRCC45 Conjugated
Short name FITC Conjugated, BRCC45 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, BRCC45 (Antibody to)
Alternative techniqueantibodies
Identity 1106
Gene BRE
Long gene name brain and reproductive organ-expressed (TNFRSF1A modulator)
Synonyms name BRCA1/BRCA2-containing complex, subunit 4
Locus 2p23, 2
Discovery year 1999-04-23
GenBank acession AF015767
Entrez gene record 9577
Pubmed identfication 9737713 7826398
Classification BRISC complex BRCA1 A complex
Havana BLAST/BLAT OTTHUMG00000097831

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