Filters

Brk (Tyr447) Antibody, ALEXA FLUOR 350

Brk (Tyr447) Antibody, ALEXA FLUOR 350 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, Brk (Tyr447) Polyclonal Antibody
Also known asAnti-Brk Tyr447 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBrk Tyr447
SpecificityThis is a highly specific antibody against Brk Tyr447
ModificationPhosphorylation
Modification SiteTyr447
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range438-451/451
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human Brk around the phosphorylation site of Tyr447 [TS(p-Y)EN]
Gene ID Number5753
Swiss ProtQ13882
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen A number of potential nuclear and cytoplasmic substrates have been identified, Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, Association with EGFR, BTK/ATK, Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p19RhoGAP, EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, EGFR, ERBB2, ERBB2, ERBB3 and IRS4, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase, Function seems to be context dependent and differ depending on cell type, In normal or non-tumorigenic tissues, In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF, Nuclear PTK6 may be important for regulating growth in normal epithelia, PTK6 activates STAT3 and STAT5B to promote proliferation, PTK6 promotes cellular differentiation and apoptosis, PXN/paxillin, STAP2/BKS, These include the RNA-binding proteins: KHDRBS1/SAM68, These proteins include ADAM15, anchorage-independent survival and migration/invasion, as well as its intracellular localization, as well as tumor growth, inactivating RhoA while activating RAS, or for which PTK6 may play an adapter-like role, thereby promoting migration and invasion, transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p19RhoGAP, which promotes association with RASA1/p12RasGAP, while cytoplasmic PTK6 might activate oncogenic signaling pathways, Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms Breast tumor kinase, PTK6, Protein-tyrosine kinase 6, Tyrosine-protein kinase BRK, BRK
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetBrk (Tyr447)
Short nameBrk (Tyr447) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, Brk (Tyr447) (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter