Filters

Btk (Ser180) Antibody

Btk (Ser180) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameBtk (Ser180) Primary Polyclonal Antibody
Also known asBtk (Ser180) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenBtk Ser180
Specificity This phosphorylation site is homologous in the listed cross reactive species at the specified location, This is a highly specific antibody against Btk Ser180
Modification(s)Phosphorylation
Modification site(s)Ser180
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range160-200/659
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human Btk around the phosphorylation site of Ser180 [GS(p-S)HR]
Gene ID number695
Swiss ProtQ06187
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ARID3A and NFAT are other transcriptional target of BTK, After BCR engagement and activation at the plasma membrane, BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways, BTK has a dual role in the regulation of apoptosis, BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B, BTK is required for the formation of functional ARID3A DNA-binding complexes, BTK plays also a critical role in transcription regulation, Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation, Especially, GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression, Induces the activity of NF-kappa-B, PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK, Plays an important role in the function of immune cells of innate as well as adaptive immunity, The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense, There is however no evidence that BTK itself binds directly to DNA, Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR, Within the TLR pathway, as a component of the Toll-like receptors (TLR) pathway, differentiation and signaling, followed by activation of the protein kinase C (PKC) family members, igniting the downstream signaling pathway through calcium mobilization, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation, is a critical molecule in regulating TLR9 activation in splenic B-cells, phosphorylates PLCG2 at several sites, which is involved in regulating the expression of hundreds of genes, Non-receptor tyrosine kinase indispensable for B lymphocyte development
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AGMX1, ATK, Agammaglobulinemia tyrosine kinase, B-cell progenitor kinase, BPK, BTK, Bruton tyrosine kinase, IMD1, PSCTK1, Tyrosine-protein kinase BTK, XLA, AT
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetBtk (Ser180)
Short nameBtk (Ser180) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameBruton agammaglobulinemia tyrosine kinase (Ser180) (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter