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Bub1 Antibody, ALEXA FLUOR 555

Bub1 Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, Bub1 Polyclonal Antibody
Also known asAnti-Bub1 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenBub1
SpecificityThis is a highly specific antibody against Bub1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range980-1030/1085
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Bub1
Gene ID Number699
Swiss ProtO43683
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1), BUB1B, CENPE and MAD2L1, Can phosphorylate BUB3, Can regulate chromosome segregation in a kinetochore-independent manner, Has a key role in the assembly of checkpoint proteins at the kinetochore, Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity, Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis, Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function, Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion, Required for the kinetochore localization of PLK1, The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20, This complex can also phosphorylate MAD1L1, being required for the subsequent localization of CENPF, Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms hBUB1 BUB1A BUB1
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetBub1
Short nameBub1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, budding uninhibited by benzimidazoles 1 homolog (yeast) (Antibody to)
Alternative techniqueantibodies
Identity 1150
Gene BUB1L
Long gene name BUB1 mitotic checkpoint serine/threonine kinase
Synonyms gene name budding uninhibited by benzimidazoles 1 (yeast homolog) budding uninhibited by benzimidazoles 1 homolog (yeast)
Locus 2q13
Discovery year 1997-08-18
GenBank acession AF046078
Entrez gene record 699
RefSeq identity NM_004336
Havana BLAST/BLAT OTTHUMG00000153638

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