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c-Kit Antibody, ALEXA FLUOR 555

c-Kit Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, c-Kit Polyclonal Antibody
Also known asAnti-c-Kit PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target Antigenc-Kit
SpecificityThis is a highly specific antibody against c-Kit
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range928-964/988
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD117/c-kit
Gene ID Number3815
Swiss ProtP10721
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Dog, Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Activated KIT also transmits signals via GRB2 and activation of RAS, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, CBL, CRK (isoform Crk-II), In response to KITLG/SCF binding, KIT can activate several signaling pathways, KIT signaling is modulated by protein phosphatases, LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, PLCG1, Phosphorylates PIK3R1, Promotes activation of STAT family members STAT1, Promotes phosphorylation of PIK3R1, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, SH2B2/APS and CBL, SRC and SHC1, STAT3, STAT3, STAT5A and STAT5B, STAT5A and STAT5B, and by rapid internalization and degradation of the receptor, and in melanogenesis, and of the transcription factors STAT1, gametogenesis, hematopoiesis, mast cell development, migration and function, stem cell maintenance, the regulatory subunit of phosphatidylinositol 3-kinase, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms CD117 SCFR C-Kit KIT
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetc-Kit
Short namec-Kit Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, c-reagent (Antibody to)
Alternative techniqueantibodies
Identity 8631
Gene PBT
Long gene name KIT proto-oncogene receptor tyrosine kinase
Synonyms gene name piebald trait v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Locus 4q12
Discovery year 1986-01-01
GenBank acession S67773
Entrez gene record 3815
Pubmed identfication 9027509
RefSeq identity NM_000222
Classification CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000128713
Locus Specific Databases LRG_307

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