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c-Met(Tyr1234 + Tyr1235) Antibody

c-Met(Tyr1234 + Tyr1235) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namec-Met(Tyr1234 + Tyr1235) Antibody
Also known asc-Met(Tyr1234 + Tyr1235) Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target Antigenc-Met Tyr1234 + Tyr1235
Specificity Due to the highly conserved nature of this domain, No phosphorylation information is currently available Rat, Ser1215 and Ser1216 in Mouse, These phosphorylation sites are homologous to Tyr1232 + Ty1233 in Mouse and Tyr1235 + Tyr1236 in Rat, in Human when phosphorylated at the the sites of Ser1238 and Ser1239 in Human, less likely, there is a chance that this antibody will react with MSP receptors in Mouse and, This is a highly specific antibody against c-Met Tyr1234 + Tyr1235
Modification(s)Phosphorylation
Modification site(s)Tyr1234 + Tyr1235
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1220-1240/1390
Subcellular locationHelical
SourceKLH conjugated synthetic phosphopeptide derived from human c-Met around the phosphorylation site of Tyr1234/1235
Gene ID number4233
Swiss ProtP08581
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a receptor for Listeria internalin inlB, During embryonic development, Following activation by ligand, GRB2, In adults, Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules, MET signaling plays a role in gastrulation, PI3 kinase-AKT, PLCG1, Promotes also differentiation and proliferation of hematopoietic cells, Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, Regulates many physiological processes including proliferation, SRC, STAT3 or the adapter GAB1, The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects, angiogenesis and kidney formation, development and migration of muscles and neuronal precursors, interacts with the PI3-kinase subunit PIK3R1, mediating entry of the pathogen into cells, morphogenesis and survival, or PLCgamma-PKC, participates in wound healing as well as organ regeneration and tissue remodeling, scattering, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AUTS9, HGF receptor, HGF/SF receptor, Hepatocyte growth factor receptor, MET, Proto-oncogene c-Met, RCCP2, SF receptor, Scatter factor receptor, Tyrosine-protein kinase Met, c-Met, HGFR
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetc-Met(Tyr1234 + Tyr1235)
Short namec-Met(Tyr1234 + Tyr1235) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namec-Met(Tyr1234 and Tyr1235) (Antibody to)
Alternative techniqueantibodies

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