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Calcineurin Antibody / PPP3CA

Calcineurin Antibody / PPP3CA size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenCalcineurin / PPP3CA
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions1-0, 5ug/ml, Western blot: 0
NotesOptimal dilution of the Calcineurin A antibody should be determined by the researcher
Intented useThis Calcineurin A antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q08209
PurityAntigen affinity
Description (1999) and Musaro et al, (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1, (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy, It is mapped to 4q24, Musaro et al, Musaro et al, Semsarian et al, Semsarian et al, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1, which accumulates in a subset of myocyte nuclei, Calcineurin A is also known as PPP3CA
ImmunogenAmino acids DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ of human Calcineurin A were used as the immunogen for the Calcineurin A antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Calcineurin A antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetCalcineurin / PPP3CA
Short nameCalcineurin Antibody / PPP3CA
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCalcineurin (Antibody to) / PPP3CA
Alternative techniqueantibodies
Identity 9314
Gene PPP3CA
Long gene name protein phosphatase 3 catalytic subunit alpha
Synonyms gene CALN CALNA
Synonyms gene name alpha isoform (calcineurin A alpha) protein phosphatase 3 (formerly 2B), alpha isoform protein phosphatase 3, alpha isozyme , catalytic subunit, catalytic subunit, catalytic subunit, protein phosphatase 3 (formerly 2B)
Synonyms CNA1 PPP2B
Synonyms name alpha isoform , calcineurin A alpha protein phosphatase 2B, catalytic subunit
Locus 4q24
Discovery year 1990-06-26
Entrez gene record 5530
Pubmed identfication 2848250 1659808
RefSeq identity NM_000944
Classification Protein phosphatase catalytic subunits
Havana BLAST/BLAT OTTHUMG00000133839

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