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CAPON Antibody

CAPON Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCAPON Primary Polyclonal Antibody
Also known asCAPON PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCAPON
SpecificityThis is a highly specific antibody against CAPON
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CAPON
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, The association of nNOS with PSD95 or PSD93 is regulated by CAPON, The carboxy terminus of CAPON binds to the PDZ domain, These proteins facilitate the transport of nNOS to the plasma membrane, and sequesters nNOS in the cytosol, but not to endothelial NOS or inducible NOS, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain, where it is catalytically activated by NMDA-receptor mediated calcium channels, CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names C terminal PDZ domain ligand of neuronal nitric oxide synthase, C terminal PDZ domain ligand of neuronal nitric oxide synthase CAPON, C terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, CAPON, CAPON_HUMAN, Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain, MGC138500, Nitric oxide synthase 1 adaptor protein, Nitric oxide synthase 1 neuronal adaptor protein, NOS1AP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCAPON
Short nameCAPON Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCAPON (Antibody to)
Alternative techniqueantibodies
Identity 16859
Gene NOS1AP
Long gene name nitric oxide synthase 1 adaptor protein
Synonyms gene name nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms KIAA0464 CAPON
Synonyms name C-terminal PDZ domain ligand of neuronal nitric oxide synthase
Locus 1q23, 3
Discovery year 2005-06-15
GenBank acession AB007933
Entrez gene record 9722
Pubmed identfication 9455484 9459447
RefSeq identity NM_014697
Havana BLAST/BLAT OTTHUMG00000024049

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