Name : CAPON Antibody, Cy7 Conjugated
Supplier : BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price :350
SKU : GEN1574160579
| Long name | Cy7 Conjugated, CAPON Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | Cy7 |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | CAPON |
| Specificity | This is a highly specific antibody against CAPON |
| Modification | Unmodified |
| Modification site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic peptide derived from human CAPON |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, The association of nNOS with PSD95 or PSD93 is regulated by CAPON, The carboxy terminus of CAPON binds to the PDZ domain, These proteins facilitate the transport of nNOS to the plasma membrane, and sequesters nNOS in the cytosol, but not to endothelial NOS or inducible NOS, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain, where it is catalytically activated by NMDA-receptor mediated calcium channels, CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS) |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | 743nm/767nm |
| Synonyms | KIAA0464 CAPON |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated | These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Gene target | CAPON Conjugated |
| Short name | Conjugated, CAPON Antibody |
| Technique | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | Cy7 |
| Alternative name | cyanine 7 coupled, CAPON (Antibody to) |
| Alternative technique | antibodies |
| Identity | 16859 |
| Gene | NOS1AP |
| Long gene name | nitric oxide synthase 1 adaptor protein |
| Synonyms gene name | nitric oxide synthase 1 (neuronal) adaptor protein |
| Synonyms name | C-terminal PDZ domain ligand of neuronal nitric oxide synthase |
| Locus | 1q23, 3 |
| Discovery year | 2005-06-15 |
| GenBank acession | AB007933 |
| Entrez gene record | 9722 |
| Pubmed identfication | 9455484 9459447 |
| RefSeq identity | NM_014697 |
| Havana BLAST/BLAT | OTTHUMG00000024049 |