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Caspase 8 Antibody

Caspase 8 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCaspase 8 Primary Polyclonal Antibody
Also known asCaspase 8 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCaspase 8
SpecificityThis is a highly specific antibody against Caspase 8
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range430-482/482
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from mouse Caspase-8 subunit p10
Gene ID number12370
Swiss ProtO89110
Tested Applications IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Ac-Asp-Glu-Val-Asp-|-AMC, Binding to the adapter molecule FADD recruits it to either receptor, CAP5 and CAP6) are likely retained in the DISC, CASP4, CASP6, CASP7, CASP9 and CASP1, Cleaves ADPRT, Cleaves and activates CASP3, Hydrolyzes the small-molecule substrate, Likely target for the cowpox virus CRMA death inhibitory protein, May participate in the GZMB apoptotic pathways, Proteolytic fragments of the N-terminal propeptide (termed CAP3, The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases, The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation, Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CASP-8, Casp8, Caspase-8, FLICE, Mch5, MACH
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCaspase 8
Short nameCaspase 8 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namecaspase 8 (Antibody to)
Alternative techniqueantibodies
Identity 1509
Gene CASP8
Long gene name caspase 8
Synonyms gene name apoptosis-related cysteine peptidase , apoptosis-related cysteine protease caspase 8, caspase 8
Synonyms MCH5 MACH FLICE Casp-8
Locus 2q33, 1
Discovery year 1996-11-11
GenBank acession U60520
Entrez gene record 841
Pubmed identfication 8681376 8681377
RefSeq identity NM_001228
Classification Caspases Death effector domain containing Ripoptosome Death inducing signaling complex
Havana BLAST/BLAT OTTHUMG00000132821
Locus Specific Databases CASP8base: Mutation registry for Caspase 8 deficiency LRG_34

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