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CBL Antibody

CBL Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenCBL
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the CBL antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis CBL antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P22681
PurityAntigen affinity
Description As such it functions as a negative regulator of many signal transduction pathways, Mutations in this gene are also the cause of Noonan syndrome-like disorder, RNF55, The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome, This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation, This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes(E2) to specific substrates, Wei et al, and E3 ubiquitin protein ligase, (1990) mapped the CBL gene to chromosome 11q23, 3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids, Casitas B lineage lymphoma proto oncogene is also known as CBL
Immunogen mouse and rat), An amino acid sequence from the C-terminus of human CBL (NLMSQGYSYQDIQKA) was used as the immunogen for this CBL antibody (100% homologous in human
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CBL antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetCBL
Short nameCBL Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name E3 ubiquitin protein ligase (Antibody to), Cbl proto-oncogene
Alternative techniqueantibodies
Alternative to gene target C-CBL and CBL2 and FRA11B and NSLL and RNF55, CBL and IDBG-631730 and ENSBTAG00000006817 and 527418, CBL and IDBG-74417 and ENSG00000110395 and 867, Cbl and IDBG-155970 and ENSMUSG00000034342 and 12402, DNA-templated and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0016600 and flotillin complex and cellular component this GO :0016874 and ligase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0042059 and negative regulation of epidermal growth factor receptor signaling pathway and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046875 and ephrin receptor binding and molecular function this GO :0048260 and positive regulation of receptor-mediated endocytosis and biological process, E3 ubiquitin protein ligase, ephrin receptor binding, nuclei, this GO :0001784 and phosphotyrosine binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006355 and regulation of transcription, this GO :0001784: phosphotyrosine binding, this GO :0001784: phosphotyrosine binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0004842: ubiquitin-protein transferase activity and also this GO :0004871: signal transducer activity and also this GO :0005509: calcium ion binding and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0016874: ligase activity and also this GO :0017124: SH3 domain binding and also this GO :0046872: metal ion binding and also this GO :0046875: ephrin receptor binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004871: signal transducer activity, this GO :0005509: calcium ion binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0016874: ligase activity, this GO :0017124: SH3 domain binding, this GO :0046872: metal ion binding, this GO :0046875: ephrin receptor binding, Cbl proto-oncogene
Identity 1541
Gene CBL
Long gene name Cbl proto-oncogene
Synonyms gene CBL2
Synonyms gene name Cas-Br-M (murine) ecotropic retroviral transforming sequence Cbl proto-oncogene, E3 ubiquitin protein ligase
Synonyms RNF55 c-Cbl
Synonyms name oncogene CBL2
Locus 11q23, 3
Discovery year 1989-06-30
GenBank acession X57110
Entrez gene record 867
Pubmed identfication 2013228
RefSeq identity NM_005188
Classification Ring finger proteins
Havana BLAST/BLAT OTTHUMG00000166170
Locus Specific Databases LRG_608

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