CCM2/Malcavernin Antibody

CCM2/Malcavernin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	CCM2/Malcavernin Primary Polyclonal Antibody
Also known as	CCM2/Malcavernin PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	CCM2/Malcavernin
Specificity	This is a highly specific antibody against CCM2/Malcavernin
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Malcavernin
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	CCM is caused by mutations in one of three genes: CCM1, CCM1 encodes the protein KRIT1, CCM2 encodes the protein Malcavernin and CCM3 shares its name with the protein it encodes, CCM2 or CCM3, Due to its lack of a nuclear export signal or nuclear localization signal, In addition, Isoform 1 represents the full length protein while isoform 2 contains an alternative four amino acid sequence rather than the first 10 residues of isoform 1, Like KRIT1, Malcavernin, Malcavernin is expresed in a variety of human organs including the arterial vascular endothelium, Malcavernin is expressed in various epithelial cells that are required for the formation of the blood-organ barrier, Malcavernin is localized to the cytoplasm but is known to shuttle to and from the nucleus, Two isoforms exist for Malcavernin, also designated cerebral cavernous malformations 2 protein, astrocytes and their foot processes, cerebral hemorrhages, headaches and focal neurologic deficits, is a scffolding protein for MEK kinase-3, it is believed that Malcavernin accomplishes this shuttling via an attachment to KRIT1, pyramidal neurons, seizures, which contains a nuclear localization signal, Cerebral cavernous malformation (CCM) is an autosomal dominant or sporadic neurovascular disease marked by vascular anomalies located mostly in the central nervous system that can cause stroke
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	CCM2_HUMAN, Ccm2, Cerebral cavernous malformation 2, Cerebral cavernous malformations 2 protein, MGC4067, MGC4607, MGC74868, Malcavernin, PP10187, C7orf22
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	CCM2/Malcavernin
Short name	CCM2/Malcavernin Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	cerebral cavernous malformation 2/Malcavernin (Antibody to)
Alternative technique	antibodies
Alternative to gene target	CCM2 and IDBG-15466 and ENSG00000136280 and 83605, CCM2 and IDBG-634072 and ENSBTAG00000008090 and 506450, Ccm2 and IDBG-148293 and ENSMUSG00000000378 and 216527, Cytoplasm, protein binding, this GO :0001568 and blood vessel development and biological process this GO :0001570 and vasculogenesis and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001885 and endothelial cell development and biological process this GO :0001944 and vasculature development and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0043234 and protein complex and cellular component this GO :0045216 and cell-cell junction organization and biological process this GO :0048839 and inner ear development and biological process this GO :0048845 and venous blood vessel morphogenesis and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0060039 and pericardium development and biological process this GO :0060837 and blood vessel endothelial cell differentiation and biological process this GO :0061154 and endothelial tube morphogenesis and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, cerebral cavernous malformation 2
Identity	21708
Gene	CCM2
Long gene name	CCM2 scaffolding protein
Synonyms gene	C7orf22
Synonyms gene name	chromosome 7 open reading frame 22 cerebral cavernous malformation 2
Synonyms	MGC4607 OSM
Synonyms name	malcavernin osmosensing scaffold for MEKK3
Locus	7p13
Discovery year	2003-07-14
GenBank acession	BC004903
Entrez gene record	83605
Pubmed identfication	9811928
RefSeq identity	NM_031443
Havana BLAST/BLAT	OTTHUMG00000129246
Locus Specific Databases	LRG_664

CCM2/Malcavernin Antibody

CCM2/Malcavernin Antibody size: 0.1ml 263

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