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CD163/M130 Antibody, Cy3 Conjugated

CD163/M130 Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, CD163/M130 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenCD163/M130
SpecificityThis is a highly specific antibody against CD163/M130
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range800-850/1156
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human CD163/M130
Gene ID number9332
Swiss ProtQ86VB7
Tested applications IF(ICC), IF(IHC-P), FCM
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background After shedding, Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype, Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells, May play a role in the uptake and recycling of iron, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions, inositol triphosphate production and secretion of IL6 and CSF1, the soluble form (sCD163) may play an anti-inflammatory role, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme, Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms M130 MM130 SCARI1
Properties 1 of the CD163/M130 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetCD163/M130 Conjugated
Short name Conjugated, CD163/M130 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, CD163 molecule/M130 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target CD163 and IDBG-16292 and ENSG00000177575 and 9332, CD163 and IDBG-639861 and ENSBTAG00000019669 and 533844, Cd163 and IDBG-186721 and ENSMUSG00000008845 and 93671, Extracellular, M130 and MM130, protein binding, this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0016020 and membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component, this GO :0005044: scavenger receptor activity, this GO :0005044: scavenger receptor activity and also this GO :0005515: protein binding, this GO :0005515: protein binding, CD163 molecule
Identity 1631
Gene CD163
Long gene name CD163 molecule
Synonyms gene name CD163 antigen
Locus 12p13, 31
Discovery year 2000-01-18
GenBank acession Z22968
Entrez gene record 9332
Pubmed identfication 10403791 8370408
RefSeq identity NM_004244 NM_203416
Classification CD molecules Scavenger receptors
Havana BLAST/BLAT OTTHUMG00000168353

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