| Long name | CD59 Primary Polyclonal Antibody |
| Also known as | CD59 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | CD59 |
| Specificity | This is a highly specific antibody against CD59 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 70-90/128 |
| Subcellular location | Helical |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD59 |
| Gene ID number | 966 |
| Swiss Prot | P13987 |
| Tested Applications | IF(IHC-P), IHC-P |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts by binding to the C8 and/or C9 complements of the assembling MAC, Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase, The soluble form from urine retains its specific complement binding activity, This inhibitor appears to be species-specific, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore, Potent inhibitor of the complement membrane attack complex (MAC) action |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | 16, 1F5 antigen, 2 kDa homologous restriction factor, CD59, CD59 glycoprotein, EJ16, EJ3, EL32, G344, HRF-2, HRF2, MAC-IP, MAC-inhibitory protein, MACIF, MEM43, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin, p18-2, 1F5, 3A5 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | CD59 |
| Short name | CD59 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | complement regulatory protein (Antibody to), CD59 molecule |
| Alternative technique | antibodies |
| Alternative to gene target | 16, CD59 and IDBG-38813 and ENSG00000085063 and 966, CD59 and IDBG-636427 and ENSBTAG00000002302 and 505574, Extracellular, complement regulatory protein, protein binding, this GO :0001775 and cell activation and biological process this GO :0001848 and complement binding and molecular function this GO :0001971 and negative regulation of activation of membrane attack complex and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007596 and blood coagulation and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0030449 and regulation of complement activation and biological process this GO :0031362 and anchored component of external side of plasma membrane and cellular component this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042383 and sarcolemma and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043218 and compact myelin and cellular component this GO :0045087 and innate immune response and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001848: complement binding, this GO :0001848: complement binding and also this GO :0005515: protein binding, this GO :0005515: protein binding, 3A5 and 1F5 and EJ16 and EJ30 and EL32 and G344 and HRF-20 and HRF20 and MAC-IP and MACIF and MEM43 and MIC11 and MIN1 and MIN2 and MIN3 and MIRL and MSK21 and p18-20, CD59 molecule |
| Identity | 1689 |
| Gene | CD59 |
| Long gene name | CD59 molecule |
| Synonyms gene | MIC11 MIN1 MSK21 MIN2 MIN3 |
| Synonyms gene name | CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16, EJ16, EJ30, EL32 and G344) CD59 antigen, complement regulatory protein , complement regulatory protein CD59 molecule, 3A5 |
| Synonyms | 16, 3A5 EJ16 EJ30 EL32 G344 p18-20 |
| Locus | 11p13 |
| Discovery year | 1989-06-30 |
| Entrez gene record | 966 |
| Pubmed identfication | 7691713 |
| RefSeq identity | NM_203329 |
| Classification | Complement system CD molecules LY6/PLAUR domain containing |
| Havana BLAST/BLAT | OTTHUMG00000166270 |
| Locus Specific Databases | CD59base: Mutation registry for CD59 deficiency LRG_41 |
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