| Long name | 116, 140, 154) Monoclonal Antibody, CD74 (1267CT820 |
| Also known as | 116, 140, 154) Monoclonal Antibody, CD74 (1267CT820 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | CD74 |
| Specificity | This is a highly specific antibody against CD74 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 116, 1267CT820, 140, 154 |
| Source | This antibody is generated from a mouse immunized with a recombinant protein |
| Gene ID number | 972 |
| Swiss Prot | P04233 |
| Tested Applications | FCM, WB |
| Recommended dilutions | FC(1:25), WB(1:1000) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Serves as cell surface receptor for the cytokine MIF, Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CD74, DHLAG, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, HLADG, Ia antigen-associated invariant chain, Ia-GAMMA, p33, II |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 116, 140, 154) Monoclonal, CD74 (1267CT820 |
| Short name | 116, 140, 154) Monoclonal Antibody, CD74 (1267CT820 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | class II invariant chain (1267CT820, major histocompatibility complex, 116, 140, 154) monoclonal (Antibody to), CD74 molecule |
| Alternative technique | antibodies |
| Alternative to gene target | BT, CD74 and IDBG-53594 and ENSG00000019582 and 972, Cd74 and IDBG-150302 and ENSMUSG00000024610 and 16149, Cell surfaces, DHLAG and HLADG and Ia-GAMMA and II, MHC class II protein binding, class II invariant chain, major histocompatibility complex, signal transduction by p53 class mediator and biological process this GO :0044183 and protein binding involved in protein folding and molecular function this GO :0045058 and T cell selection and biological process this GO :0045059 and positive thymic T cell selection and biological process this GO :0045060 and negative thymic T cell selection and biological process this GO :0045581 and negative regulation of T cell differentiation and biological process this GO :0045582 and positive regulation of T cell differentiation and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050998 and nitric-oxide synthase binding and molecular function this GO :0051085 and chaperone mediated protein folding requiring cofactor and biological process this GO :0060907 and positive regulation of macrophage cytokine production and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071556 and integral component of lumenal side of endoplasmic reticulum membrane and cellular component this GO :0090023 and positive regulation of neutrophil chemotaxis and biological process this GO :1902166 and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :2000343 and positive regulation of chemokine (C-X-C motif) ligand 2 production and biological process, this GO :0000139 and this GO lgi membrane and cellular component this GO :0000187 and activation of MAPK activity and biological process this GO :0001516 and prostaglandin biosynthetic process and biological process this GO :0001540 and beta-amyloid binding and molecular function this GO :0001961 and positive regulation of cytokine-mediated signaling pathway and biological process this GO :0002606 and positive regulation of dendritic cell antigen processing and presentation and biological process this GO :0002792 and negative regulation of peptide secretion and biological process this GO :0002830 and positive regulation of type 2 immune response and biological process this GO :0002906 and negative regulation of mature B cell apoptotic process and biological process this GO :0004896 and cytokine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005764 and lysosome and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005770 and late endosome and cellular component this GO :0005771 and multivesicular body and cellular component this GO :0005773 and vacuole and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006952 and defense response and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0008283 and cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0012507 and ER to this GO lgi transport vesicle membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016064 and immunoglobulin mediated immune response and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0019883 and antigen processing and presentation of endogenous antigen and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0019955 and cytokine binding and molecular function this GO :0023026 and MHC class II protein complex binding and molecular function this GO :0030658 and transport vesicle membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0030669 and clathrin-coated endocytic vesicle membrane and cellular component this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032588 and trans- this GO lgi network membrane and cellular component this GO :0035691 and macrophage migration inhibitory factor signaling pathway and biological process this GO :0035692 and macrophage migration inhibitory factor receptor complex and cellular component this GO :0035693 and NOS2-CD74 complex and cellular component this GO :0035718 and macrophage migration inhibitory factor binding and molecular function this GO :0042289 and MHC class II protein binding and molecular function this GO :0042613 and MHC class II protein complex and cellular component this GO :0042658 and MHC class II protein binding, this GO :0001540: beta-amyloid binding, this GO :0001540: beta-amyloid binding and also this GO :0004896: cytokine receptor activity and also this GO :0005515: protein binding and also this GO :0019955: cytokine binding and also this GO :0023026: MHC class II protein complex binding and also this GO :0035718: macrophage migration inhibitory factor binding and also this GO :0042289: MHC class II protein binding and also this GO :0042658: MHC class II protein binding, this GO :0004896: cytokine receptor activity, this GO :0005515: protein binding, this GO :0019955: cytokine binding, this GO :0023026: MHC class II protein complex binding, this GO :0035718: macrophage migration inhibitory factor binding, this GO :0042289: MHC class II protein binding, this GO :0042658: MHC class II protein binding, this GO :0042802: identical protein binding, this GO :0044183: protein binding involved in protein folding, this GO :0050998: nitric-oxide synthase binding, via antigen binding groove, via antigen binding groove and also this GO :0042802: identical protein binding and also this GO :0044183: protein binding involved in protein folding and also this GO :0050998: nitric-oxide synthase binding, via antigen binding groove and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0043030 and regulation of macrophage activation and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043202 and lysosomal lumen and cellular component this GO :0043518 and negative regulation of DNA damage response, 46809 and IDBG-646288 and ENSBTAG00000015228 and 613384, CD74 molecule |
| Identity | 1697 |
| Gene | CD74 |
| Long gene name | CD74 molecule |
| Synonyms gene | DHLAG |
| Synonyms gene name | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) CD74 molecule, class II invariant chain , major histocompatibility complex |
| Synonyms name | HLA-DR-gamma Ia-associated invariant chain gamma chain of class II antigens MHC HLA-DR gamma chain |
| Locus | 5q33, 1 |
| Discovery year | 1986-01-01 |
| Entrez gene record | 972 |
| Pubmed identfication | 6324166 3001652 |
| RefSeq identity | NM_004355 |
| Classification | CD molecules |
| Havana BLAST/BLAT | OTTHUMG00000163559 |
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