| Alternative name 1 | B-Cell, Clone: BU45, IH/flow/IP, MHC Class II Assoc, Mab anti-Hu, Macrophage, Monocyte, frozen/paraffin, gp41/35/33, CD74 |
| Alternative name 2 | B-Cell, Clone: BU45, IH/flow/IP, MHC Class II Assoc, Mab antibody-Hu, Macrophage, Monocyte, frozen/paraffin, gp41/35/33, CD74 |
| Alternative name 3 | B-Cell, Clone: BU45, IH/flow/IP, MHC Class II Assoc, Mab antibody-Hu, Macrophage, Monocyte, frozen/paraffin, gp41/35/33, CD74 |
| Alternative name 4 | anti-CD74 B-Cell Monocyte Macrophage MHC Class II Assoc gp41/35/33 Clone: BU45 Hu |
| Alternative name 5 | CD74 B-Cell Monocyte Macrophage MHC Class II Assoc gp41/35/33 Clone: BU45 Hu |
| Clonality | Monoclonal Antibody |
| Description | Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, If used correctly and according the protocol, in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications, This is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against |
| Storage and handling | Antibodies in a liquid form can be shipped and stored for a short period of time at +4 degrees Celsius, antibodies that are lyophilized can be transported at ambient temperature and stored for short terms at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol should be added and then the container has to be stored at -20°, for longer periods - at -20 , C, Generally |
| Advisory | For antibodies in a liquid form or reconstituted lyophilized antibodies small amounts of the soultion could be captured on the cap or the walls of the container, Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom, To keep the quality and the affinity of the antibody cycles of freezing and thawing should be avoided |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| French translation | anticorps |
| Gene target | B Monocyte, BU45, IH/ /IP, MHC Class II Assoc, Macrophage, Monoclonal Hu, frozen/paraffin, gp41/35/33, CD74 |
| Short name | B-Cell, Clone: BU45, IH/ /IP, MHC Class II Assoc, Macrophage, Monocyte, Mouse Monoclonal antibody-Hu, frozen/paraffin, gp41/35/33, CD74 |
| Technique | Monoclonals or monoclonal antibodies, mouses, paraffin |
| Species | Mouses, Mouse |
| Alternative name | -25°, B-cellular, IH/flow/IP, Macrophage, Major histocompabitility complex Class II Assoc, Monocyte, Mouse monoclonal (Antibody to)-Hu, class II invariant chain, clonality: BU45, gp41/35/33, major histocompatibility complex, C frozen/paraffin, CD74 molecule |
| Alternative technique | murine |
| Alternative to gene target | BT, CD74 and IDBG-53594 and ENSG00000019582 and 972, Cd74 and IDBG-150302 and ENSMUSG00000024610 and 16149, Cell surfaces, DHLAG and HLADG and Ia-GAMMA and II, MHC class II protein binding, class II invariant chain, major histocompatibility complex, signal transduction by p53 class mediator and biological process this GO :0044183 and protein binding involved in protein folding and molecular function this GO :0045058 and T cell selection and biological process this GO :0045059 and positive thymic T cell selection and biological process this GO :0045060 and negative thymic T cell selection and biological process this GO :0045581 and negative regulation of T cell differentiation and biological process this GO :0045582 and positive regulation of T cell differentiation and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050998 and nitric-oxide synthase binding and molecular function this GO :0051085 and chaperone mediated protein folding requiring cofactor and biological process this GO :0060907 and positive regulation of macrophage cytokine production and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071556 and integral component of lumenal side of endoplasmic reticulum membrane and cellular component this GO :0090023 and positive regulation of neutrophil chemotaxis and biological process this GO :1902166 and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :2000343 and positive regulation of chemokine (C-X-C motif) ligand 2 production and biological process, this GO :0000139 and this GO lgi membrane and cellular component this GO :0000187 and activation of MAPK activity and biological process this GO :0001516 and prostaglandin biosynthetic process and biological process this GO :0001540 and beta-amyloid binding and molecular function this GO :0001961 and positive regulation of cytokine-mediated signaling pathway and biological process this GO :0002606 and positive regulation of dendritic cell antigen processing and presentation and biological process this GO :0002792 and negative regulation of peptide secretion and biological process this GO :0002830 and positive regulation of type 2 immune response and biological process this GO :0002906 and negative regulation of mature B cell apoptotic process and biological process this GO :0004896 and cytokine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005764 and lysosome and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005770 and late endosome and cellular component this GO :0005771 and multivesicular body and cellular component this GO :0005773 and vacuole and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006952 and defense response and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0008283 and cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0012507 and ER to this GO lgi transport vesicle membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016064 and immunoglobulin mediated immune response and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0019883 and antigen processing and presentation of endogenous antigen and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0019955 and cytokine binding and molecular function this GO :0023026 and MHC class II protein complex binding and molecular function this GO :0030658 and transport vesicle membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0030669 and clathrin-coated endocytic vesicle membrane and cellular component this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032588 and trans- this GO lgi network membrane and cellular component this GO :0035691 and macrophage migration inhibitory factor signaling pathway and biological process this GO :0035692 and macrophage migration inhibitory factor receptor complex and cellular component this GO :0035693 and NOS2-CD74 complex and cellular component this GO :0035718 and macrophage migration inhibitory factor binding and molecular function this GO :0042289 and MHC class II protein binding and molecular function this GO :0042613 and MHC class II protein complex and cellular component this GO :0042658 and MHC class II protein binding, this GO :0001540: beta-amyloid binding, this GO :0001540: beta-amyloid binding and also this GO :0004896: cytokine receptor activity and also this GO :0005515: protein binding and also this GO :0019955: cytokine binding and also this GO :0023026: MHC class II protein complex binding and also this GO :0035718: macrophage migration inhibitory factor binding and also this GO :0042289: MHC class II protein binding and also this GO :0042658: MHC class II protein binding, this GO :0004896: cytokine receptor activity, this GO :0005515: protein binding, this GO :0019955: cytokine binding, this GO :0023026: MHC class II protein complex binding, this GO :0035718: macrophage migration inhibitory factor binding, this GO :0042289: MHC class II protein binding, this GO :0042658: MHC class II protein binding, this GO :0042802: identical protein binding, this GO :0044183: protein binding involved in protein folding, this GO :0050998: nitric-oxide synthase binding, via antigen binding groove, via antigen binding groove and also this GO :0042802: identical protein binding and also this GO :0044183: protein binding involved in protein folding and also this GO :0050998: nitric-oxide synthase binding, via antigen binding groove and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0043030 and regulation of macrophage activation and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043202 and lysosomal lumen and cellular component this GO :0043518 and negative regulation of DNA damage response, 46809 and IDBG-646288 and ENSBTAG00000015228 and 613384, CD74 molecule |
| Identity | 1697 |
| Gene | CD74 |
| Long gene name | CD74 molecule |
| Synonyms gene | DHLAG |
| Synonyms gene name | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) CD74 molecule, class II invariant chain , major histocompatibility complex |
| Synonyms name | HLA-DR-gamma Ia-associated invariant chain gamma chain of class II antigens MHC HLA-DR gamma chain |
| Locus | 5q33, 1 |
| Discovery year | 1986-01-01 |
| Entrez gene record | 972 |
| Pubmed identfication | 6324166 3001652 |
| RefSeq identity | NM_004355 |
| Classification | CD molecules |
| Havana BLAST/BLAT | OTTHUMG00000163559 |
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