| Long name | CDK4 Primary Polyclonal Antibody |
| Also known as | CDK4 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | CDK4 |
| Specificity | This is a highly specific antibody against CDK4 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 250-303/303 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CDK4 |
| Gene ID number | 1019 |
| Swiss Prot | P11802 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity, Component of the ternary complex, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Hypophosphorylates RB1 in early G(1) phase, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex, Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CDK4, Cell division protein kinase 4, Cyclin-dependent kinase 4, PSK-J3, CMM3 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | CDK4 |
| Short name | CDK4 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | cyclin-dependent kinase 4 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | CDK4 and IDBG-43642 and ENSG00000135446 and 1019, CMM3 and PSK-J3, Cdk4 and IDBG-194056 and ENSMUSG00000006728 and 102641469, nuclei, this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0000785 and chromatin and cellular component this GO :0002088 and lens development in camera-type eye and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004693 and cyclin-dependent protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005923 and tight junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010033 and response to organic substance and biological process this GO :0010288 and response to lead ion and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010971 and positive regulation of G2/M transition of mitotic cell cycle and biological process this GO :0016301 and kinase activity and molecular function this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004693: cyclin-dependent protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016301: kinase activity and also this GO :0016772: transferase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004693: cyclin-dependent protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016301: kinase activity, this GO :0016772: transferase activity, this GO :0030332: cyclin binding, this GO :0032403: protein complex binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0030332: cyclin binding and also this GO :0032403: protein complex binding, transferring phosphorus-containing groups and molecular function this GO :0030332 and cyclin binding and molecular function this GO :0031100 and organ regeneration and biological process this GO :0031965 and nuclear membrane and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0033574 and response to testosterone and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045727 and positive regulation of translation and biological process this GO :0045793 and positive regulation of cell size and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051301 and cell division and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0071157 and negative regulation of cell cycle arrest and biological process, 12567, cyclin-dependent kinase 4 |
| Identity | 1773 |
| Gene | CDK4 |
| Long gene name | cyclin dependent kinase 4 |
| Synonyms | PSK-J3 |
| Locus | 12q14, 1 |
| Discovery year | 1993-07-28 |
| GenBank acession | M14505 |
| Entrez gene record | 1019 |
| Pubmed identfication | 8275715 |
| RefSeq identity | NM_000075 |
| Classification | Cyclin dependent kinases |
| Havana BLAST/BLAT | OTTHUMG00000170382 |
| Locus Specific Databases | LRG_490 |
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