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CDK4 Antibody, Biotin Conjugated

CDK4 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, CDK4 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenCDK4
SpecificityThis is a highly specific antibody against CDK4
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range250-303/303
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human CDK4
Gene ID number1019
Swiss ProtP11802
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity, Component of the ternary complex, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Hypophosphorylates RB1 in early G(1) phase, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex, Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms PSK-J3
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetCDK4 Conjugated
Short name Conjugated, CDK4 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, cyclin-dependent kinase 4 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target CDK4 and IDBG-43642 and ENSG00000135446 and 1019, CMM3 and PSK-J3, Cdk4 and IDBG-194056 and ENSMUSG00000006728 and 102641469, nuclei, this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0000785 and chromatin and cellular component this GO :0002088 and lens development in camera-type eye and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004693 and cyclin-dependent protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005923 and tight junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010033 and response to organic substance and biological process this GO :0010288 and response to lead ion and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010971 and positive regulation of G2/M transition of mitotic cell cycle and biological process this GO :0016301 and kinase activity and molecular function this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004693: cyclin-dependent protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016301: kinase activity and also this GO :0016772: transferase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004693: cyclin-dependent protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016301: kinase activity, this GO :0016772: transferase activity, this GO :0030332: cyclin binding, this GO :0032403: protein complex binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0030332: cyclin binding and also this GO :0032403: protein complex binding, transferring phosphorus-containing groups and molecular function this GO :0030332 and cyclin binding and molecular function this GO :0031100 and organ regeneration and biological process this GO :0031965 and nuclear membrane and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0033574 and response to testosterone and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045727 and positive regulation of translation and biological process this GO :0045793 and positive regulation of cell size and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051301 and cell division and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0071157 and negative regulation of cell cycle arrest and biological process, 12567, cyclin-dependent kinase 4
Identity 1773
Gene CDK4
Long gene name cyclin dependent kinase 4
Locus 12q14, 1
Discovery year 1993-07-28
GenBank acession M14505
Entrez gene record 1019
Pubmed identfication 8275715
RefSeq identity NM_000075
Classification Cyclin dependent kinases
Havana BLAST/BLAT OTTHUMG00000170382
Locus Specific Databases LRG_490

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