CDK7 (45H1) Monoclonal Antibody

CDK7 (45H1) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 362

Size 0.1ml

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Long name	CDK7 (45H1) Monoclonal Antibody
Also known as	CDK7 (45H1) Monoclonal Antibody
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	CDK7
Specificity	This is a highly specific antibody against CDK7
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Monoclonal
Clone number	45H1
Concentration	1ug per 1ul
Source	), Recombinant human protein purified from E, a, coli(His/ABD-CDK7 136-346 a
Gene ID number	1022
Swiss Prot	P50613
Tested Applications	IP, WB
Recommended dilutions	0 ug), 2 ug/mL) IP (2, WB (0
Cross reactivity	Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	CAK activates the cyclin-associated kinases CDK1, CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), CDK1, CDK2, CDK2, CDK4, CDK4 and CDK6 by threonine phosphorylation, CDK6 and CDK11B/CDK11, CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle, Each different complex controls a specific transition between 2 subsequent phases in the cell cycle, Its expression and activity are constant throughout the cell cycle, POLR2A, Phosphorylates SPT5/SUPT5H, Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA, Required for DNA-bound peptides-mediated transcription and cellular growth inhibition, Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, SF1/NR5A1, Upon DNA damage, allowing its escape from the promoter and elongation of the transcripts, and for activation of CDK2/cyclins during G1-S transition (but not complex formation), but is inactivated in turn by p53/TP53, helping in cell recovery, or to apoptosis, p53/TP53, this feedback loop may lead to an arrest of the cell cycle and of the transcription, thus regulating cell cycle progression, triggers p53/TP53 activation by phosphorylation, Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription
Purification method	Purified by Protein G
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	39 kDa protein kinase, CAK1, CDK-activating kinase 1, CDK7, CDKN7, Cell division protein kinase 7, Cyclin-dependent kinase 7, HCAK, MO15, STK1, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit, p39 Mo15, p39MO15, CAK
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About	Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target	CDK7 (45H1) Monoclonal
Short name	CDK7 (45H1) Monoclonal Antibody
Technique	Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name	CDK7 (45H1) monoclonal (Antibody to)
Alternative technique	antibodies
Identity	1778
Gene	CDK7
Long gene name	cyclin dependent kinase 7
Synonyms gene name	Xenopus laevis, cdk-activating kinase) , cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) cyclin-dependent kinase 7 (MO15 homolog
Synonyms	CAK1 CDKN7 MO15 STK1 CAK
Locus	5q13, 2
Discovery year	1994-12-16
Entrez gene record	1022
Pubmed identfication	8069918
RefSeq identity	NM_001799
Classification	Cyclin dependent kinases
Havana BLAST/BLAT	OTTHUMG00000099358

CDK7 (45H1) Monoclonal Antibody

CDK7 (45H1) Monoclonal Antibody size: 0.1ml 362

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