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CDK9 Antibody, ALEXA FLUOR 350

CDK9 Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, CDK9 Polyclonal Antibody
Also known asAnti-CDK9 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenCDK9
SpecificityThis is a highly specific antibody against CDK9
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range250-300/372
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CDK9
Gene ID Number1025
Swiss ProtP50750
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth, H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, In addition, MYOD1, Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), P-TEFb is also involved in cotranscriptional histone modification, Phosphorylates EP300, Promotes RNA synthesis in genetic programs for cell growth, Promotes cardiac myocyte enlargement, RPB1/POLR2A and AR, RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription, Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e, Replication stress response protein, SUPT5H and RDBP, TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling), The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro, This complex is inactive when in the 7SK snRNP complex form, also called positive transcription elongation factor b (P-TEFb), and the negative elongation factors DSIF and NELF, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, differentiation and viral pathogenesis, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing, mRNA processing and mRNA export, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6, the CDK9/cyclin-K complex is required for genome integrity maintenance, thus reducing the breakdown of stalled replication forks and avoiding DNA damage, which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, Protein kinase involved in the regulation of transcription, g
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms PITALRE C-2k TAK
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetCDK9
Short nameCDK9 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, CDK9 (Antibody to)
Alternative techniqueantibodies
Identity 1780
Gene CDK9
Long gene name cyclin dependent kinase 9
Synonyms gene CDC2L4
Synonyms gene name cyclin-dependent kinase 9 (CDC2-related kinase)
Locus 9q34, 11
Discovery year 1998-04-29
GenBank acession L25676
Entrez gene record 1025
Pubmed identfication 8170997 9356449
Classification Cyclin dependent kinases P-TEFb complex
Havana BLAST/BLAT OTTHUMG00000020715

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